Patient no. | Sex | Age (y) | Age at onset (y) | Duration of epilepsy (y) | Duration of status epilepticus (d) | MRI at time of PET | Neuropsychologic findings at time of PET | Ictal EEG during status epilepticus | Main seizure signs during FIRES chronic stage | Ictal EEG during FIRES chronic stage | Interictal spikes during FIRES chronic stage |
1 | F | 9.8 | 4.3 | 5.5 | 8 | Bilateral HH, left HA | FIQ, 61; VIQ, 64; PIQ, 67 (WISC-III); standardized score, PPVT-R = 83; reduced word fluency; severe memory deficit (RBMT = 8/22); behavior disorders; slowness and perseverations | — | Right DHE, left clonia | Right hemisphere | Left temporal |
2 | F | 10.4 | 4.5 | 5.9 | 8 | Normal | Mental deficiency; IQ < 50 (Terman Merill test); aphasia and auditory agnosia; attention problems and hyperactivity; aggressive behavior | Right temporofrontal | Staring, fear, crying, mouth deviation (G) | Right temporofrontal | Left hemisphere |
3 | M | 9.3 | 4.6 | 4.7 | 6 | Normal | Reduced receptive language; antisocial behavior, aggression | — | Staring, eyelid and arm clonia | Left and right temporofrontal | Left temporofrontal |
4 | M | 6.2 | 4.7 | 1.5 | 60 | Bilateral HH, bilateral HA | Untestable; loss of speech; major behavior disorders | Left and right temporal | Staring, agitation, right clonia | Left and right temporooccipital | Left and right temporooccipital |
5 | M | 8.8 | 6.2 | 2.6 | 17 | Normal | Mental deficiency; IQ < 45 (WPPSI-III); language disorders; anxiety/depression | Left occipital | Generalized tonic–clonic | Left and right frontal | Right temporal |
6 | M | 7.9 | 6.8 | 2 | 15 | Normal | VIQ, 97; PIQ, 77; attention deficit hyperactivity | — | Left DHE, left limb clonia, 4 limbs tonic | Right temporal | Left temporal |
7 | F | 9.3 | 6.9 | 2.4 | 56 | Bilateral HH, bilateral HA | Reduced mental ability; FIQ, 51; VIQ, 60; PIQ, 53; standardized score, PPVT-R = 79; reduced speech production; severe memory deficit (RBMT = 3/22); attention problems and hyperactivity; thought problems | — | Staring, left mouth deviation, eyelid clonia | Left and right temporal | Left and right temporal |
8 | M | 12.9 | 8.6 | 4.3 | 21 | Generalized cerebral atrophy | Reduced mental ability; FIQ, 54; VIQ, 60; PIQ 68; standardized score, PPVT-R = 78; speech fluency disorder; memory deficit (RBMT = 14/22); anxiety/depression; slowness and perseverations | — | Staring, left mouth and arm clonia, eyelid clonia (G) | Left and right frontal | Left and right frontal |
DHE = deviation of head and eyes; FIQ = full-scale IQ; (G) = tonic–clonic generalization ; HA = hippocampal atrophy; HH = hippocampal hypersignal; PIQ = performance IQ; PPVT-R = Peabody Picture Vocabulary Test-Revised; RBMT = Rivermead Behavior Memory Test; VIQ = verbal IQ; WISC-III = Wechsler Intelligence Scale for Children; WPPSI = Wechsler Preschool and Primary Scale of Intelligence.