Parameter Estimates of Reversible 1-Tissue-Compartment Model for Asymptomatic Patients
Region | IF | K1 (mLplasma· min−1· mLextravascular tissue−1) | k2 (min−1) | Blood volume | VT (mLplasma· mLextravascular tissue−1) | Residual sum of square errors |
Bone marrow | Total-plasma BSIF | 0.111 ± 0.049 | 0.043 ± 0.013 | 0.196 ± 0.129 | 2.479 ± 0.513 | 3.569 ± 3.982 |
Parent-plasma BSIF | 0.151 ± 0.072 | 0.024 ± 0.010 | 0.171 ± 0.123 | 6.036 ± 0.749 | 3.911 ± 3.937 | |
Total-plasma IDIF | 0.088 ± 0.034 | 0.039 ± 0.008 | 0.036 ± 0.055 | 2.510 ± 0.545 | 3.000 ± 2.925 | |
Parent-plasma IDIF | 0.108 ± 0.045 | 0.017 ± 0.006 | 0.027 ± 0.058 | 6.017 ± 0.929 | 4.002 ± 2.583 | |
Lung parenchyma | Total-plasma BSIF | −5.153 ± 10.313* | 2.541 ± 4.829 | 1.292 ± 1.574* | −0.496 ± 1.075* | 6.734 ± 5.159 |
Parent-plasma BSIF | −0.173 ± 0.356* | 0.379 ± 0.595 | 0.675 ± 0.342 | −0.074 ± 0.329* | 7.322 ± 5.364 | |
Total-plasma IDIF | 0.036 ± 0.008 | 0.205 ± 0.066 | 0.280 ± 0.112 | 0.187 ± 0.042 | 3.225 ± 3.375 | |
Parent-plasma IDIF | 0.034 ± 0.005 | 0.120 ± 0.046 | 0.287 ± 0.114 | 0.313 ± 0.121 | 3.607 ± 3.747 | |
Mean of aortic walls (descending, arch, ascending) | Total-plasma BSIF | −3.805 ± 5.076* | 2.222 ± 2.130 | 1.839 ± 1.465* | −0.710 ± 1.123* | 22.412 ± 22.544 |
Parent-plasma BSIF | −0.445 ± 0.579* | 0.577 ± 0.513 | 1.016 ± 0.522* | −0.133 ± 0.958* | 30.433 ± 21.391 | |
Total-plasma IDIF | 0.014 ± 0.008 | 0.050 ± 0.023 | 0.449 ± 0.121 | 0.275 ± 0.119 | 6.863 ± 5.327 | |
Parent-plasma IDIF | 0.016 ± 0.009 | 0.030 ± 0.012 | 0.449 ± 0.120 | 0.580 ± 0.248 | 6.829 ± 5.269 |
↵* Blood volume (bv) > 1, K negative, VT negative.
Data are mean ± SD (n = 4). For all regions considered, kinetic parameters were computed for 4 BSIFs and IDIFs.