Ki (nM) of… | Reduction (%) in specific signal after block with PBR28 (50 nM) | ||
Binding class | PBR111 | PBR111 after block with PBR28 (50 nM) | |
HABs | 15.6 ± 3.7 (n = 5) | Not measurable | 69.0 ± 4.6 (n = 4) |
LABs | 61.8 ± 10.7 (n = 5) | 51.7 ± 12.2 (n = 4) | 21.2 ± 4.8 (n = 4) |
MABs | 30.3 ± 4.1 (n = 4) | 54.4 ± 5.3 (n = 4) | 49.3 ± 2.9 (n = 4) |
t test | |||
HAB vs LAB | P < 0.003 | NA | P < 0.0004 |
MAB vs LAB | P < 0.04 | P < 0.84 | P < 0.002 |
MAB vs HAB | P < 0.03 | NA | P < 0.01 |
NA = not applicable.
Data are expressed as mean ± SEM.