TABLE 2

Competition Binding Studies with PBR111 in Absence and Presence of 50 nM of PBR28

Ki (nM) of…Reduction (%) in specific signal after block with PBR28 (50 nM)
Binding classPBR111PBR111 after block with PBR28 (50 nM)
HABs15.6 ± 3.7 (n = 5)Not measurable69.0 ± 4.6 (n = 4)
LABs61.8 ± 10.7 (n = 5)51.7 ± 12.2 (n = 4)21.2 ± 4.8 (n = 4)
MABs30.3 ± 4.1 (n = 4)54.4 ± 5.3 (n = 4)49.3 ± 2.9 (n = 4)
t test
 HAB vs LABP < 0.003NAP < 0.0004
 MAB vs LABP < 0.04P < 0.84P < 0.002
 MAB vs HABP < 0.03NAP < 0.01
  • NA = not applicable.

  • Data are expressed as mean ± SEM.