Competition Binding Studies with PK11195, PBR28, PBR06, PBR111, DPA713, and DAA1106
| Ki (nM) of… | ||||||
| Binding class | PK11195* | PBR28* | PBR06 | DPA713 | DAA1106 | PBR111 |
| HABs | 28.3 ± 4.0 (n = 6) | 3.4 ± 0.2 (n = 6) | 8.6 ± 2.0 (n = 5) | 15.0 ± 2.2 (n = 5) | 2.8 ± 0.3 (n = 4) | 15.6 ± 3.7 (n = 5) |
| LABs | 22.3 ± 2.2 (n = 5) | 188 ± 7.0 (n = 5) | 149 ± 46.6 (n = 4) | 66.4 ± 7.8 (n = 4) | 13.1 ± 1.3 (n = 4) | 61.8 ± 10.7 (n = 5) |
| MABs | 23.6 ± 5.5 (n = 4) | Two receptors detected (n = 4): 4.0 ± 1.2 (high) and 313 ± 38 (low) | Two receptors detected (n = 4): 13.4 ± 3.4 (high) and 176 ± 103 (low) | 26.8 ± 2.9 (n = 4) | 4.8 ± 0.4 (n = 4) | 30.3 ± 4.1 (n = 4) |
| Ki ratio of LAB to HAB | 0.8 | 55 | 17 | 4.4 | 4.7 | 4.0 |
| t test | ||||||
| HAB vs. LAB | P < 0.25 | P < 0.0001 | P < 0.011 | P < 0.001 | P < 0.001 | P < 0.003 |
| MAB vs. LAB | P < 0.82 | NA | NA | P < 0.003 | P < 0.001 | P < 0.04 |
| MAB vs. HAB | P < 0.50 | NA | NA | P < 0.01 | P < 0.005 | P < 0.03 |
↵* Data reproduced from Owen et al. (6).
NA = not applicable.
Data are expressed as mean ± SEM. All data in Table 1 were generated from donors B1–B15, inclusive.