Biodistribution and Tumor-to-Organ Ratio of 77Br-MBBG and 125I-MIBG in PC-12–Bearing Mice
| Time after injection | ||||
| Tracer/organ | 30 min | 1 h | 3 h | 6 h |
| 77Br-MBBG | ||||
| Blood | 0.86 ± 0.11 | 0.83 ± 0.02 | 0.59 ± 0.10 | 0.52 ± 0.03 |
| Liver | 8.39 ± 0.45 | 7.62 ± 0.37 | 3.95 ± 0.37 | 2.30 ± 0.11 |
| Kidney | 2.03 ± 0.28 | 1.62 ± 0.12 | 1.36 ± 0.18 | 1.07 ± 0.17 |
| Intestine | 5.45 ± 0.45 | 4.83 ± 0.16 | 4.93 ± 0.59 | 3.58 ± 0.23 |
| Stomach | 2.24 ± 0.30 | 2.16 ± 0.21 | 2.18 ± 0.58 | 1.43 ± 0.32 |
| Heart | 16.81 ± 1.71 | 13.24 ± 0.95 | 14.16 ± 5.25 | 9.04 ± 0.73 |
| Adrenal | 14.85 ± 3.35 | 12.86 ± 2.57 | 16.50 ± 4.21 | 17.27 ± 4.38 |
| Muscle | 1.11 ± 0.43 | 1.01 ± 0.17 | 1.04 ± 0.24 | 0.75 ± 0.15 |
| Tumor | 20.29 ± 7.50 | 22.00 ± 10.33 | 32.00 ± 18.60 | 23.71 ± 5.91 |
| Tumor-to-blood ratio | 23.4 ± 7.9 | 26.2 ± 12.0 | 54.4 ± 31.9 | 45.2 ± 10.1 |
| Tumor-to-muscle ratio | 20.2 ± 10.1 | 23.1 ± 12.4 | 33.1 ± 24.9 | 33.1 ± 13.5 |
| 125I-MIBG | ||||
| Blood | 1.00 ± 0.14 | 0.91 ± 0.05 | 0.55 ± 0.12 | 0.32 ± 0.04 |
| Liver | 8.52 ± 0.65 | 7.78 ± 0.42 | 4.17 ± 0.42 | 2.23 ± 0.12 |
| Kidney | 2.29 ± 0.33 | 1.69 ± 0.13 | 1.36 ± 0.25 | 0.94 ± 0.19 |
| Intestine | 5.35 ± 0.43 | 4.92 ± 0.23 | 5.39 ± 0.60 | 3.79 ± 0.22 |
| Stomach | 3.20 ± 0.54 | 2.96 ± 0.07 | 3.15 ± 0.58 | 1.95 ± 0.43 |
| Heart | 14.82 ± 1.53 | 11.39 ± 0.74 | 12.52 ± 4.67 | 8.10 ± 0.68 |
| Adrenal | 12.44 ± 1.69 | 9.92 ± 1.78 | 12.62 ± 4.12 | 11.39 ± 3.23 |
| Muscle | 1.02 ± 0.45 | 0.87 ± 0.15 | 0.92 ± 0.23 | 0.63 ± 0.12 |
| Tumor | 16.17 ± 6.15 | 18.11 ± 8.28 | 25.11 ± 14.95 | 19.35 ± 4.94 |
| Tumor-to-blood ratio | 16.2 ± 5.8 | 19.6 ± 8.3 | 46.4 ± 27.4 | 61.4 ± 14.6 |
| Tumor-to-muscle ratio | 17.8 ± 8.8 | 21.7 ± 11.0 | 28.7 ± 20.1 | 32.2 ± 13.3 |
Each value represents mean ± SD of 5 animals. Values are expressed as percentage injected dose per gram of organ except for tumor-to-blood and tumor-to-muscle ratios.