Demographic and Clinical Characteristics of Subjects
| HD | |||
| Parameter | All (n = 20) | Early (n = 7) | Control (n = 14) |
| Sex (n) | |||
| M | 8 | 3 | 6 |
| F | 12 | 4 | 8 |
| Age (y) | 53.3 ± 12.1 (32.3–83.1) | 47.3 ± 11.6 (32.3–64.5) | 54.3 ± 12.9 (30.7–68.5) |
| Weight (kg) | 65.9 ± 11.1 (50.0–89.0)* | 71.7 ± 9.9 (60.0–89.0) | 75.7 ± 10.6 (58.0–95.0) |
| (CAG)n | 43.6 ± 2.8 (39–50) | 44.3 ± 3.9 (40–50) | — |
| Estimated disease duration (y) | 6.0 ± 5.5 (0.5–19.4) | 1.9 ± 1.5 (0.5–4.5) | — |
| UHDRS motor score | 35.2 ± 25.0 (8–80) | 15.0 ± 6.1 (8–27) | — |
| UHDRS TFC score | 6.4 ± 4.8 (0–13) | 11.9 ± 0.9 (11–13) | — |
| Shoulson–Fahn stage | — | ||
| I | 7 | 7 | |
| II | 3 | 0 | |
| III | 4 | 0 | |
| IV | 4 | 0 | |
| V | 2 | 0 | |
| Handedness | |||
| L | 2 | 0 | 3 |
| Ambidexter | 0 | 0 | 1 |
| R | 18 | 7 | 10 |
↵* Significant difference between patients and controls (P < 0.05).
Values represent mean ± SD, with range in parentheses. UHDRS motor scale ranges from 0 to 124, with higher scores indicating more motor impairment. UHDRS TFC scale assesses ability to perform daily activities and ranges from 13 (no impairment) to 0 (total incapacity). TFC scores are further subdivided into 5 Shoulson–Fahn stages: I (representing TFC scores 11–13), II (scores 7–10), III (scores 3–6), IV (scores 1–2), and V (score 0).