TABLE 1.

DAT Imaging in Parkinsonism, Related Movement Disorders, and Other Neurodegenerative Disorders

DiseaseDAT availability
PD↓↓/↓↓↓*
Atypical parkinsonism (multiple-system atrophy, progressive supranuclear palsy)↓↓/↓↓↓*
Essential tremor↔†
Drug-induced or psychogenic parkinsonism↔
Vascular parkinsonism↔
↓
Huntington disease↓↓
DLB↓↓/↓↓↓*
AD↔/↓
Frontotemporal dementia↓
↓↓

  • ↵* Moderate to severe reduction depending on stage of disease.

  • ↵† In the U.S. 123I-β-CIT study, a reduction of DAT availability has been reported in 5 patients with essential tremor.

  • ↓ = mild reduction of DAT availability; ↓↓ = moderate reduction of DAT availability; ↓↓↓ = severe reduction of DAT availability; ↔ = no change in DAT availability.