Organ | 24 h (n = 4) | 48 h (n = 5) | 96 h (n = 5) | 144 h (n = 4) | Block (300 μg of mAb) at 48 h (n = 4) |
Blood | 21.8 ± 2.8 | 4.4 ± 1.9 | 1.4 ± 0.8 | 2.6 ± 1.5 | 10.7 ± 0.4 |
Tumor | 34.4 ± 3.2 | 38.0 ± 6.2 | 40.4 ± 4.8 | 45.8 ± 3.2 | 10.3 ± 0.8 |
Heart | 7.4 ± 2.2 | 4.0 ± 1.3 | 1.7 ± 0.6 | 1.4 ± 0.5 | 3.8 ± 0.7 |
Lung | 11.7 ± 1.9 | 5.7 ± 3.1 | 2.2 ± 0.9 | 2.5 ± 0.9 | 5.7 ± 0.3 |
Liver | 11.7 ± 1.5 | 17.7 ± 1.6 | 17.2 ± 2.7 | 11.2 ± 1.6 | 5.1 ± 0.4 |
Spleen | 8.8 ± 4.3 | 21.1 ± 0.3 | 24.6 ± 1.8 | 4.6 ± 2.4 | 3.1 ± 0.7 |
Kidney | 10.1 ± 1.0 | 7.5 ± 1.5 | 5.1 ± 0.5 | 5.3 ± 0.5 | 5.1 ± 0.2 |
Muscle | 1.1 ± 0.1 | 0.6 ± 0.3 | 0.4 ± 0.4 | 0.2 ± 0.2 | 0.8 ± 0.2 |
Bone | 4.0 ± 0.8 | 8.2 ± 1.2 | 8.7 ± 1.5 | 7.4 ± 1.3 | 2.4 ± 0.3 |
Tumor/blood | 1.6 ± 0.2 | 8.7 ± 4.1 | 29.7 ± 17.1 | 18.0 ± 10.5 | 1.0 ± 0.1 |
Tumor/heart | 4.7 ± 1.5 | 9.6 ± 3.5 | 23.4 ± 9.0 | 31.9 ± 10.7 | 2.7 ± 0.5 |
Tumor/lung | 2.9 ± 0.5 | 6.7 ± 3.7 | 18.4 ± 7.7 | 18.5 ± 6.8 | 1.8 ± 0.2 |
Tumor/liver | 2.9 ± 0.5 | 2.1 ± 0.4 | 2.3 ± 0.5 | 4.1 ± 0.7 | 2.0 ± 0.2 |
Tumor/spleen | 3.9 ± 1.9 | 1.8 ± 0.3 | 1.6 ± 0.2 | 9.9 ± 5.2 | 3.3 ± 0.8 |
Tumor/kidney | 3.4 ± 0.5 | 5.1 ± 1.3 | 7.9 ± 1.2 | 8.6 ± 1.1 | 2.0 ± 0.2 |
Tumor/muscle | 32.4 ± 4.6 | 59.2 ± 28.8 | 95.9 ± 95.3 | 306.4 ± 432.2 | 13.3 ± 3.1 |
Tumor/bone | 8.7 ± 1.9 | 4.7 ± 1.0 | 4.6 ± 1.0 | 6.2 ± 1.2 | 4.3 ± 0.6 |
Complete biodistribution data are presented in Supplemental Table 7. Data are expressed as mean %ID/g ± SD. Errors for tumor-to-tissue ratios are calculated as geometric mean of SD. LNCaP tumors: 3–4 μg mAb; PSMA-positive, 50–250 mm3.