Tissue | Uptake (%IA/g) 111In-ABY-025 | 111In-DOTA-ZHER2:2395-C | 111In-DOTA-ZHER2:342-pep2 |
---|---|---|---|
Blood | 0.21 ± 0.03 | 0.19 ± 0.05 | 0.11 ± 0.03 |
Lung | 0.4 ± 0.2 | 0.4 ± 0.1 | 0.3 ± 0.1 |
Liver | 1.7 ± 0.7 | 1.5 ± 0.3 | 1.7 ± 0.3 |
Spleen | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.49 ± 0.07 |
Colon | 0.3 ± 0.1 | 0.25 ± 0.04 | 0.19 ± 0.05 |
Kidney | 184 ± 48 | 181 ± 17 | 184 ± 20 |
Tumor | 11 ± 3 | 11 ± 2 | 14 ± 1 |
Muscle | 0.10 ± 0.04 | 0.07 ± 0.01 | 0.07 ± 0.01 |
Bone | 0.3 ± 0.1 | 0.20 ± 0.05 | 0.22 ± 0.08 |
Gastrointestinal tract† | 0.93 ± 0.08 | 1.8 ± 0.8 | 0.8 ± 0.2 |
Carcass | 4 ± 1 | 3.2 ± 0.5 | 2.5 ± 0.4 |
Data are presented as average from 4 animals ± SD. Uptake is calculated as %IA/g. Data for gastrointestinal tract (with its content) and carcass are presented as %IA per whole sample.