Spatial Correlation Between 89Zr-cG250-F(ab′)2 Autoradiography and Immunohistochemical Signal of CAIX and Pimonidazole
| 89Zr-cG250-F(ab′)2 vs. CAIX | 89Zr-cG250-F(ab′)2 vs. pimonidazole | |||
|---|---|---|---|---|
| Time after injection of 89Zr-cG250-F(ab′)2 (h) | Mean correlation coefficient (r) | Mean slope (α) | Mean correlation coefficient (r) | Mean slope (α) |
| 4 (n = 4) | 0.68 ± 0.06 | 0.31 ± 0.15 | 0.54 ± 0.08 | 0.25 ± 0.07 |
| 24 (n = 4) | 0.62 ± 0.04 | 0.36 ± 0.28 | 0.61 ± 0.09 | 0.38 ± 0.11 |
| All (n = 8) | 0.65 ± 0.05 | 0.33 ± 0.21 | 0.58 ± 0.09 | 0.31 ± 0.11 |
Data are given as mean ± SD. Correlation coefficients (r) and mean linear regression slopes (α) result from 200 × 200 μm pixel-by-pixel comparison between 89Zr-cG250-F(ab′)2 autoradiography images and immunohistochemical signal images of CAIX and pimonidazole.