Biodistribution in Rip1Tag2 Mice at 0.5, 2, 4, and 18 Hours After Injection of [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-Exendin-4
| Organ | 0.5 h | 2 h | 4 h | 18 h |
|---|---|---|---|---|
| Lungs* | 14.6 ± 4.3 | 18.5 ± 5.9 | 15.9 ± 5.6 | 8.7 ± 1.9 |
| Pancreas* | 7.1 ± 2.0 | 9.6 ± 1.5 | 7.4 ± 2.2 | 6.0 ± 1.4 |
| Stomach* | 1.18 ± 0.32 | 1.36 ± 0.32 | 1.20 ± 0.30 | 1.05 ± 0.27 |
| Tumor* | 67 ± 13 | 98 ± 19 | 93 ± 20 | 50 ± 9 |
| Kidneys | 63 ± 10 | 57 ± 14 | 60 ± 12 | 42 ± 12 |
| Liver | 0.83 ± 0.20 | 0.71 ± 0.28 | 0.72 ± 0.20 | 0.74 ± 0.19 |
| Spleen | 0.59 ± 0.10 | 0.47 ± 0.17 | 0.52 ± 0.10 | 0.58 ± 0.10 |
| Muscle | 0.16 ± 0.08 | 0.13 ± 0.10 | 0.17 ± 0.08 | 0.09 ± 0.05 |
| Bone | 0.19 ± 0.03 | 0.16 ± 0.03 | 0.18 ± 0.03 | 0.21 ± 0.02 |
| Blood | 2.34 ± 0.47 | 0.55 ± 0.11 | 0.35 ± 0.13 | 0.19 ± 0.12 |
| Tumor/blood | 29 | 177 | 266 | 262 |
| Tumor/muscle | 419 | 754 | 547 | 556 |
| Tumor/pancreas | 9.5 | 10.2 | 12.6 | 8.4 |
| Tumor/lungs | 4.59 | 5.29 | 5.86 | 10.6 |
| Tumor/kidneys | 1.06 | 1.72 | 1.55 | 1.18 |
↵* GLP-1 receptor–positive organs.
Results are expressed as %IA/g (mean ± SD), n ≥ 3.