TABLE 2

Biodistribution in Rip1Tag2 Mice at 0.5, 1, 2, and 4 Hours After Injection of [Lys40(Ahx-DOTA-68Ga)NH2]-Exendin-4

Organ0.5 h1 h2 h4 h
Lungs*40.8 ± 3.542.5 ± 5.131.4 ± 2.942.5 ± 5.1
Pancreas*17.0 ± 2.413.5 ± 4.416.8 ± 6.313.5 ± 1.0
Stomach*4.05 ± 0.334.08 ± 0.592.56 ± 0.352.14 ± 0.77
Tumor*185 ± 33209 ± 44207 ± 60205 ± 59
Kidneys255 ± 14230 ± 33252 ± 24202 ± 34
Liver0.88 ± 0.040.61 ± 0.110.63 ± 0.120.61 ± 0.11
Spleen2.14 ± 0.121.91 ± 0.502.10 ± 0.732.28 ± 0.59
Muscle1.30 ± 0.101.13 ± 0.510.97 ± 0.091.00 ± 1.03
Bone1.03 ± 0.331.01 ± 0.911.07 ± 0.130.89 ± 0.52
Blood2.08 ± 0.491.35 ± 0.170.49 ± 0.030.29 ± 0.10
Tumor/blood88.9155423706
Tumor/muscle142185214205
Tumor/pancreas10.915.512.415.2
Tumor/lungs4.524.916.604.82
Tumor/kidneys0.720.910.821.01
  • * GLP-1 receptor–positive organs.

  • Results are expressed as %IA/g (mean ± SD), n ≥ 3.