Comparison of Internalization Kinetics for 111In-, 67Ga-, and 99mTc-Labeled Exendin-4 in β-Tumor Cells
| Compound | 0.5 h | 1 h | 2 h | 4 h |
|---|---|---|---|---|
| [Lys40(Ahx-DOTA-111In)NH2]-exendin-4 | 1.03 ± 0.14 | 2.03 ± 0.18 | 4.97 ± 0.4 | 9.75 ± 0.65 |
| [Lys40(Ahx-DOTA-67Ga)NH2]-exendin-4 | 1.22 ± 0.08 | 2.48 ± 0.29 | 5.10 ± 0.26 | 10.35 ± 0.43 |
| [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 | 0.73 ± 0.29 | 1.50 ± 0.49 | 3.37 ± 1.27 | 6.50 ± 1.94 |
| 1-way ANOVA | P = 0.002 | P = 0.001 | P = 0.003 | P = 0.0001 |
Values and SD are result of 2 independent experiments (triplicates in each experiment) and are expressed as specific internalization (% added radioactivity/106 cells ± SD). Significance was analyzed by 1-way ANOVA.