Characteristic | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 |
---|---|---|---|---|---|---|---|---|
Sex | M | M | F | F | M | M | F | F |
Age (y) | 71 | 71 | 66 | 53 | 62 | 55 | 73 | 73 |
Handedness | R | R | R | R | R | R | L | R |
Essential tremor family history | No | Yes | No | Yes | Yes | Yes | Yes | Yes |
Disease duration (y) | 52 | 10 | 6 | 7 | 30 | 40 | 50 | 43 |
Tremor distribution | UE (LE) | UE | UE | UE | UE | UE | UE | UE |
Tremor characteristics | Postural | Postural/kinetic | Postural/kinetic | Postural/kinetic | Postural/kinetic | Postural/kinetic | Postural | Postural/kinetic |
Dominant side of tremor (UE) | R > L | L > R | L > R | R > L | L > R | R > L | L = R | L > R |
Tremor frequency (UE) (Hz) | 6 | 6 | 6 | 8 | 5 | 5 | 6 | 6 |
Tremor amplitude (UE)* | 3 | 4 | 3 | 2 | 2 | 3 | 4 | 2 |
Head tremor | Mild | None | Mild | None | Mild | Mild | Moderate | Mild |
Vocal tremor | None | None | Moderate | None | Mild | None | Severe | None |
Current tremor medication | GP | None | None | None | None | None | None | MP |
Previous tremor medication† | None | PR; P | None | None | P | PR; GP; P | MP; P | None |
Alcohol responsiveness | Yes | Not known | Not known | No | Yes | Yes | Yes | Yes |
TSH, basal (mU/I) | 0.6 | 1.5 | 3.4 | 0.2‡ | 1.3 | 0.5 | 0.5 | 1.8 |
CRST, part 1 | 31 | 42 | 27 | 12 | 22 | 25 | 43 | 26 |
↵* Tremor amplitude, derived from CRST, point 3: arms outstretched, wrist mildly extended, fingers spread apart (0 = none; 1 = slight amplitude [<0.5 cm], may be intermittent; 2 = moderate amplitude [0.5–1 cm], may be intermittent; 3 = marked amplitude [1–2 cm]; 4 = severe amplitude [>2 cm]).
↵† Withdrawn before PET, accounting for respective half-lives of compounds.
↵‡ Measured in patient receiving 25 μg of levothyroxine-natrium for goiter therapy.
CRST = Clinical Rating Scale for Tremor (20), with maximum of 80 points for part 1; UE = upper extremities; LE = lower extremities; PR = propranolol; P = primidone; GP = gabapentin; MP = metoprolol; TSH = thyroid-stimulating hormone.