Calculation of Absorbed Kidney Dose After 111In-DTPA-Exendin-4 Administration
| 3 h after injection | 24 h after injection | |||||||
|---|---|---|---|---|---|---|---|---|
| Mouse group | Injected activity (MBq) | Total MBq | % Injected activity | Total MBq | % Injected activity | Kidney mass (mg) | mGy/MBq | Absorbed dose (Gy) |
| Female | ||||||||
| WT | 42.4 ± 3.0 | 27.2 ± 2.6 | 64.0 ± 2.2 | 15.5 ± 1.7 | 44.4 ± 2.9 | 140 ± 13 | 1.66 ± 0.15 | 73 ± 9 |
| Megalin-deficient | 42.6 ± 4.7 | 16.1 ± 3.9 | 37.8 ± 8.1 | 8.5 ± 2.4 | 24.6 ± 6.2 | 156 ± 17 | 0.86 ± 0.23 | 38 ± 11 |
| Male | ||||||||
| WT | 39.2 ± 3.5 | 33.2 ± 3.3 | 69.3 ± 1.4 | 16.3 ± 1.4 | 42.7 ± 3.5 | 189 ± 11 | 1.46 ± 0.10 | 72 ± 6 |
| Megalin-deficient | 35.5 ± 3.1 | 17.5 ± 2.9 | 42.0 ± 8.2 | 7.0 ± 1.3 | 20.7 ± 4.8 | 225 ± 14 | 0.50 ± 0.11 | 21 ± 4 |
Data are mean ± SD.