Biodistribution of CDR-Grafted Nanobodies Based on Dissection at 2.5 Hours After Injection
| Organ or tissue | DC1.8 graft | P | DC2.1 graft | P |
|---|---|---|---|---|
| Lungs | 24.11 ± 3.21 | <0.01 | 14.05 ± 1.54 | <0.01 |
| Liver | 1.83 ± 0.35 | 0.03 | 16.90 ± 2.80 | <0.01 |
| Spleen | 6.07 ± 0.67 | <0.01 | 109.44 ± 2.68 | <0.01 |
| Heart | 7.93 ± 0.49 | <0.01 | 5.16 ± 1.07 | <0.01 |
| Left kidney | 58.77 ± 5.16 | 55.67 ± 11.90 | ||
| Right kidney | 62.25 ± 11.47 | 59.73 ± 2.56 | ||
| Skin | 1.16 ± 0.18 | <0.01 | 0.81 ± 0.05 | <0.01 |
| Muscle | 1.27 ± 0.38 | <0.01 | 0.88 ± 0.11 | <0.01 |
| Blood | 1.06 ± 0.28 | 0.47 | 8.04 ± 0.67 | <0.01 |
Data are percentage of injected activity (mean ± SD) per gram of tissue. P values represent difference with Nb-BCII10 and are based on 2-tailed unpaired t test.