SB in All Striatal Regions, Ratios, and Absolute Lateralization Indices in Patients with IPS and Non-IPS
| IPS | Non-IPS | Sensitivity (%) | Specificity (%) | Accuracy (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Binding and region | Mean ± SD | Range | Mean ± SD | Range | P | ROC (AUC ± SE) | NPV (%) | PPV (%) | |||
| Dopamine D2/3–specific binding | |||||||||||
| Striatum | 2.16 ± 0.32 | 1.52–2.96 | 1.55 ± 0.28 | 0.86–2.00 | <0.001 | 0.936 ± 0.027 | 86.5 | 90.9 | 88.9 | 88.9 | 88.9 |
| Caudate nucleus | 1.91 ± 0.32 | 1.23–2.66 | 1.48 ± 0.25 | 0.84–1.98 | <0.001 | 0.859 ± 0.041 | 73.0 | 86.4 | 79.2 | 81.8 | 80.2 |
| Putamen | 2.23 ± 0.33 | 1.60–3.04 | 1.57 ± 0.31 | 0.79–2.08 | <0.001 | 0.944 ± 0.024 | 86.5 | 93.2 | 89.1 | 91.4 | 90.1 |
| Anterior putamen | 2.12 ± 0.31 | 1.54–2.97 | 1.62 ± 0.28 | 1.00–2.12 | <0.001 | 0.894 ± 0.036 | 83.8 | 86.4 | 86.4 | 83.8 | 85.2 |
| Posterior putamen | 2.42 ± 0.39 | 1.67–3.31 | 1.49 ± 0.42 | 0.46–2.13 | <0.001 | 0.970 ± 0.016 | 86.5 | 95.5 | 89.4 | 94.1 | 91.4 |
| P-to-NC ratio | 1.18 ± 0.10 | 1.07 ± 0.20 | <0.01 | 0.690 ± 0.058 | 81.1 | 47.7 | 75.0 | 56.6 | 63.0 | ||
| PP-to-NC ratio | 1.27 ± 0.13 | 1.02 ± 0.28 | <0.001 | 0.830 ± 0.045 | 81.1 | 75.0 | 82.5 | 73.2 | 77.8 | ||
| PP-to-PA ratio | 1.14 ± 0.09 | 0.91 ± 0.18 | <0.001 | 0.907 ± 0.032 | 83.8 | 81.8 | 85.7 | 79.5 | 82.7 | ||
| Combination SBPP and PP-to-PA ratio | — | — | — | — | 97.3 | 84.1 | 97.4 | 83.7 | 90.1 | ||
| ALI | |||||||||||
| Striatum | 0.05 ± 0.04 | 0.10 ± 0.10 | <0.01 | 0.372 ± 0.062 | 45.9 | 43.2 | 48.7 | 40.5 | 44.4 | ||
| Caudate nucleus | 0.08 ± 0.07 | 0.10 ± 0.06 | >0.05 | 0.357 ± 0.063 | 62.2 | 20.5 | 39.1 | 39.7 | 39.5 | ||
| Anterior putamen | 0.05 ± 0.03 | 0.10 ± 0.11 | <0.01 | 0.329 ± 0.059 | 75.7 | 11.4 | 35.7 | 41.8 | 40.7 | ||
| Posterior putamen | 0.08 ± 0.06 | 0.17 ± 0.18 | <0.01 | 0.340 ± 0.060 | 86.5 | 11.4 | 50.0 | 45.1 | 45.7 | ||
| Discriminant analysis (SBPP, PP-to-PA ratio, and PP-to-NC ratio) | — | — | — | — | 91.9 | 95.5 | 93.3 | 94.4 | 93.8 | ||
Level of significance from Student t test (P); AUC with respective SE from ROC analysis; and sensitivity, specificity, NPV, PPV, and accuracy for optimal specific binding threshold are presented.