TABLE 1

Comparison of Outcomes from Full Kinetic Modeling and Simplified Methods

	1TC			SRTM (BP_ND)	Logan reference (BP_ND)	Ratio, 200–240 min (BP_ND)
Region	V_T	BP_P	BP_ND	SRTM (BP_ND)	Logan reference (BP_ND)	Ratio, 200–240 min (BP_ND)
Cerebellum	8.7 ± 2.3	—	—	—	—	—
Midbrain	19.2 ± 4.9	10.4 ± 3.3	1.2 ± 0.3	1.4 ± 0.2^*	1.3 ± 0.2	1.7 ± 0.4
Thalamus	21.6 ± 6.8	12.9 ± 4.8	1.5 ± 0.40	1.5 ± 0.4	1.4 ± 0.4	1.8 ± 0.4
Putamen	20.1 ± 6.3	11.4 ± 4.3	1.3 ± 0.3	1.2 ± 0.3	1.2 ± 0.3	1.4 ± 0.3
Caudatus	18.7 ± 5.8	10.0 ± 3.8	1.1 ± 0.3	1.1 ± 0.3	1.1 ± 0.3	1.4 ± 0.3
Superior frontal cortex	14.5 ± 4.4	5.8 ± 2.7	0.7 ± 0.3	0.7 ± 0.3	0.7 ± 0.3	0.6 ± 0.3
Occipital cortex	11.8 ± 2.7	3.1 ± 1.3	0.4 ± 0.2	0.3 ± 0.2	0.3 ± 0.2	0.3 ± 0.2

↵* Mean BP_ND in midbrain from SRTM was calculated after exclusion of 2 outliers.
1TC = 1-tissue-compartment model; SRTM = simplified reference tissue model; V_T = total distribution volume; BP_P = binding potential, calculated as V_T(ROI) − V_{T(Cerebellum)}; BP_ND = ratio at equilibrium of specific to nondisplaceable radioligand binding, calculated as BP_P/V_{T(Cerebellum)} for 1TC model.
Values are mean ± SD (n = 7). V_T and BP_P were determined with 1TC analysis. BP_ND values were derived using 1TC model, SRTM, Logan reference with individual estimation of k2′ by SRTM model, or ratio method based on data 200–240 min after injection.