TABLE 1

Organ-to-Background Ratios (OBRs) and %ID/g of ¹⁸F-MEL050 in Tissues of C57BL/6 Mice Bearing B16-F0 Tumor Allografts

	Tumor		Eyes		Spleen		Thyroid
Time (h)	OBR	%ID/g	OBR	%ID/g	OBR	%ID/g	OBR	%ID/g
1	19.3 ± 1.9	9.6 ± 0.5	6.9 ± 1.1	2.9 ± 0.2	7.7 ± 0.9	3.7 ± 0.4	5.0 ± 0.9	2.2 ± 0.2
2	50.9 ± 6.9*	9.3 ± 0.7	14.9 ± 2.2^†	2.2 ± 0.1^†	13.7 ± 1.6*	2.9 ± 0.4	4.1 ± 0.4	0.9 ± 0.1^†
3	54.3 ± 10.5*	9 ± 0.6	21 ± 2.5^†	1.7 ± 0.04^‡,§	16.8 ± 1.6*	2.6 ± 0.4	5 ± 0.9	0.6 ± 0.1^†

1 h vs. 2 or 3 h: *P < 0.05; ^†P < 0.01; ^‡P < 0.001, or 2 h vs. 3 h: ^§P < 0.01, as determined by t test.
Tissue uptake calculated from PET images after intravenous injection of 29.6 MBq of ¹⁸F-MEL050 is expressed as mean ± SEM (n = 6).