TABLE 2

In Vivo Imaging Signals (Expressed as Video Intensities) Obtained with Different Types of Microbubbles in SKOV-3 Tumors and Muscle in Mice

Mean ± SD video intensity in study:
Type of microbubble1 (SKOV-3 tumors)2 (SKOV-3 tumors)3 (SKOV-3 tumors)4 (SKOV-3 tumors)5 (Muscle)
MB-KnottinIntegrin11.9 ± 6.19.1 ± 6.415.5 ± 5.613.2 ± 7.01.3 ± 0.3*
MBαvβ35.6 ± 2.3†
MBcRGD7.1 ± 7.9‡
MB-KnottinScrambled5.2 ± 1.0*
MB-KnottinIntegrin after blocking4.7 ± 4.0*

  • ↵* P < 0.05.

  • ↵† P < 0.01.

  • ↵‡ Not significant.

  • SKOV-3 = human ovarian adenocarcinoma xenograft; muscle = hind limb muscle tissue (control).