TABLE 1

Biologic Half-Lives and Initial Cell Retention from Endothelial Progenitor Cell Injections

GroupHeart–to–whole body ratio, on injection dayLong half-life (h)
Epicardial injection, day 0
 Dog 158%48.44
 Dog 2*59.70
 Dog 351%50.89
 Dog 456%84.39
 Dog 569%40.56
 Dog 632%82.62
 Dog 774%113.31
 Mean ± SD57% ± 15%68.6 ± 25.9
Endocardial injection, day 0
 Dog 878%55.99
 Dog 972%68.60
 Dog 1082%83.62
 Dog 1160%90.16
 Mean ± SD73% ± 10%†74.6 ± 15.3‡
Endocardial injection, week 1
 Dog 1244%42.11
 Dog 1320%40.49
 Dog 1419%41.46
 Mean ± SD28% ± 14%†41.3 ± 0.8‡
Total endocardial mean ± SD54% ± 26%60.4 ± 20.8

  • ↵* Whole-body SPECT image not acquired.

  • ↵† P = 0.004 between cell retention (heart–to–whole body ratio) for endocardial injection at day 0 vs. week 1.

  • ↵‡ P = 0.015 between half-life of cell clearance of endocardial injection at day 0 vs. week 1.