TABLE 2

Pattern of Model Selection

							Model 1 parameter values			Model 2a parameter values						SUV_bw maximum 30 min after injection
Patient no.			Model (BIC values)						Bound fraction						Bound fraction
Patient no.	Scan	Tumor	1	2a	2b	3	V	k_trap	Bound fraction	V	k₁	k₂	k_trap	K_i	Bound fraction
1	Before	1	*1.20*	1.27	1.29	1.29	0.050 (0.031)	0.115 (0.004)	0.95	0.033 (0.032)	0.126 (0.008)	0.004 (0.003)	0.000 (0.000)	0.000	0.00	8.0
1	After 1	1	*0.94*	1.03	1.02	1.17	0.027 (0.029)	0.074 (0.004)	0.96	0.000 (0.000)	0.199 (0.237)	1.507 (4.246)	0.952 (0.994)	0.077	0.99	4.5
1	After 2	1	*0.32*	0.42	0.51	0.65	0.001 (0.015)	0.037 (0.002)	1.00	0.000 (0.000)	0.042 (0.007)	0.015 (0.041)	0.078 (0.211)	0.035	0.78	2.3
2	Before	1	*2.16*	2.29	2.28	2.43	0.042 (0.066)	0.120 (0.009)	0.96	0.000 (0.000)	0.237 (0.347)	0.763 (3.779)	0.829 (1.783)	0.124	0.99	11.2
2	After	1	1.35	*1.28*	1.37	1.52	0.010 (0.035)	0.096 (0.005)	0.99	0.000 (0.000)	0.138 (0.023)	0.073 (0.074)	0.154 (0.102)	0.093	0.93	6.8
3	Before	1	2.09	*1.29*	1.86	2.00	0.185 (0.090)	0.036 (0.011)	0.63	0.000 (0.000)	0.166 (0.017)	0.080 (0.016)	0.018 (0.006)	0.031	0.47	3.3
4	Before	1	0.88	0.91	*0.77*	0.83	0.027 (0.006)	0.090 (0.002)	0.97	0.017 (0.010)	0.139 (0.051)	0.259 (0.507)	0.467 (0.506)	0.089	0.96	6.6
4	Before	2	*1.78*	1.87	1.83	1.80	0.054 (0.022)	0.063 (0.005)	0.91	0.025 (0.047)	0.210 (0.292)	0.828 (2.228)	0.364 (0.382)	0.064	0.93	5.5
4	After	1	*1.10*	1.25	1.22	1.33	0.045 (0.018)	0.103 (0.004)	0.95	Collapsed to model 1						5.5
4	After	2	*1.04*	1.15	1.21	1.31	0.138 (0.032)	0.070 (0.005)	0.81	0.125 (0.037)	0.083 (0.022)	0.013 (0.044)	0.032 (0.216)	0.058	0.41	4.5
5	After	1	*0.71*	0.79	0.84	0.98	0.054 (0.014)	0.054 (0.003)	0.90	0.040 (0.020)	0.100 (0.068)	0.304 (0.775)	0.360 (0.478)	0.054	0.90	3.1
5	After	2	*0.60*	0.74	0.64	0.81	0.111 (0.020)	0.055 (0.003)	0.81	Collapsed to model 1						3.3
5	After	1	*0.61*	0.67	0.78	1.20	0.000 (0.019)	0.078 (0.003)	0.81	0.000 (0.000)	0.09 (0.003)	0.01 (0.002)	0.00 (0.000)	0.000	0.90	4.5
5	After	2	*0.90*	0.94	1.10	1.80	0.005 (0.005)	0.026 (0.002)	0.81	0.000 (0.000)	0.05 (0.011)	0.11 (0.014)	0.12 (0.014)	0.024	0.90	1.6
6	Before	1	*1.55*	1.70	1.77	1.92	0.267 (0.032)	0.074 (0.005)	0.70	Collapsed to model 1						10.1
6	Before	2	*1.25*	1.28	1.44	1.58	0.200 (0.017)	0.094 (0.003)	0.80	0.189 (0.018)	0.106 (0.010)	0.008 (0.015)	0.012 (0.129)	0.062	0.19	11.0
6	Before	3	*1.67*	1.81	1.76	1.89	0.227 (0.041)	0.059 (0.006)	0.69	Collapsed to model 1						8.1
7	After 2	1	2.28	*1.64*	1.73	2.18	0.179 (0.101)	0.120 (0.014)	0.85	0.002 (0.055)	0.276 (0.032)	0.073 (0.022)	0.045 (0.016)	0.106	0.71	8.2
8	Before	1	1.13	*0.17*	0.80	0.94	0.057 (0.031)	0.054 (0.004)	0.89	0.006 (0.012)	0.092 (0.006)	0.035 (0.009)	0.022 (0.014)	0.036	0.43	3.5
8	After	1	1.78	*1.62*	1.79	1.94	0.000 (0.000)	0.183 (0.003)	1.00	0.000 (0.000)	0.241 (0.026)	0.040 (0.032)	0.097 (0.062)	0.170	0.86	11.5
9	Before	1	*1.71*	1.83	1.78	1.92	0.080 (0.042)	0.032 (0.006)	0.77	0.065 (0.046)	0.041 (0.012)	0.013 (0.013)	0.000 (0.000)	0.000	0.00	3.1
9	After	1	1.79	*1.17*	1.45	1.59	0.093 (0.050)	0.041 (0.007)	0.79	0.000 (0.000)	0.209 (0.037)	0.381 (0.129)	0.109 (0.021)	0.046	0.91	4.1
10	Before	1	*1.74*	1.88	1.85	1.99	0.009 (0.043)	0.036 (0.006)	0.97	0.004 (0.048)	0.039 (0.012)	0.005 (0.014)	0.000 (0.000)	0.000	0.00	3.1
10	After	1	1.99	1.98	2.04	*1.96*	0.119 (0.054)	0.088 (0.007)	0.86	0.077 (0.052)	0.115 (0.014)	0.014 (0.005)	0.000 (0.000)	0.000	0.00	7.9
11	Before	1	1.49	*1.03*	1.60	1.19	0.063 (0.029)	0.070 (0.004)	0.90	0.022 (0.019)	0.100 (0.009)	0.022 (0.012)	0.021 (0.031)	0.048	0.38	7.2
11	After	1	1.18	1.09	*1.05*	1.19	0.153 (0.032)	0.031 (0.004)	0.63	0.053 (0.066)	0.290 (0.306)	1.444 (1.695)	0.236 (0.066)	0.041	0.84	3.2
12^*	Before	1
13^*	Before	1

↵* No ¹⁸F-FDHT uptake was observed for patients 12 and 13; therefore, these patients were excluded from further analysis.
Units for k_trap, k₁, k_2, and K_i are all 1/min. V parameters are unitless, as are bound fraction and SUV normalized by body weight; (SUV_bw). Bolded and italicized BIC values are minimums. Values in parentheses are SD. Before = before therapy; after = after therapy.