Baseline and Postoperative UPDRS Motor Ratings and Operative Changes
| Subject group | Pre | Post 1 y | Post 2 y | Post 4 y | Δ1 (%) | Δ2 (%) | Δ4 (%) |
|---|---|---|---|---|---|---|---|
| All | 38.3 ± 2.0* | 32.6 ± 2.6 | 26.5 ± 2.8 | 28.1 ± 2.7 | −15.1 ± 2.0†‡ | −30.8 ± 4.8§ | −24.9 ± 4.7‡ |
| Young (≤60 y) | 38.5 ± 2.6 | 29.6 ± 3.6 | 21.4 ± 2.9 | 29.5 ± 4.0 | −23.1 ± 4.4 | −44.6 ± 9.2 | −23.8 ± 5.6 |
| Older (>60 y) | 38.1 ± 3.2 | 36.0 ± 3.5 | 31.7 ± 4.3 | 25.4 ± 2.3 | −5.3 ± 1.0 | −16.8 ± 3.7 | −27.4 ± 7.8 |
| Men | 38.4 ± 3.1 | 28.5 ± 3.9 | 25.9 ± 4.3 | 28.1 ± 4.3 | −25.8 ± 5.6 | −32.6 ± 8.0 | −21.5 ± 5.8 |
| Women | 38.2 ± 2.7 | 35.9 ± 3.3 | 27.0 ± 3.7 | 28.2 ± 3.5 | −6.0 ± 1.0 | −29.3 ± 6.1 | −28.5 ± 7.7 |
↵* Off-state UPDRS motor ratings (mean ± SE) at baseline (pre) and 1 (post 1 y), 2 (post 2 y), and 4 (post 4 y) years after transplantation.
↵† Δ = (postoperative – baseline)/baseline × 100%. More negative values reflect greater improvement in parkinsonian signs.
↵‡ P < 0.05, compared with baseline (1-way RMANOVA from 33 transplant recipients over 2 y [Δ1 and Δ2] and 15 of these subjects over 4 y [Δ4]).
↵§ P < 0.0001, compared with baseline (1-way RMANOVA from 33 transplant recipients over 2 y [Δ1 and Δ2] and 15 of these subjects over 4 y [Δ4]).