TABLE 1

SERT and DAT Binding Affinity of Inhibitor (Ki), as Measured in Rat Brain Homogenates

LigandKi DAT (nM), 3H-GBR-12935Ki SERT (nM), 3H-paroxetineSERT-to-DAT ratio
123I-β-CIT*2730.1
123I-FP-CIT†3.59.72.8
123I-PE2I*1750029.4

  • ↵* According to study of Abi-Dargham et al. (5).

  • ↵† According to study of Emond et al. (8).