Mechanisms of Radiopharmaceutical Accumulation in Inflamed Tissue
| Radiopharmaceutical | Mechanism |
| 18F-FDG | Macrophages (metabolically active cells), leukocytes |
| 99mTc/111In-labeled autologous WBCs (leukocytes) | Active migration into sites of inflammation |
| 99mTc-labeled bisphosphonates | Uptake in sites of increased perfusion and extravasation (early phase) and increased bone formation (late phase) |
| 67Ga-citrate | Increased perfusion, extravasation due to increased vessel permeability, locally binding to lactoferrin |
| 99mTc-labeled nanocolloids | Uptake in macrophages (inflammation, bone marrow, liver, spleen) |
| 99mTc/111In-labeled proteins (IgG, albumin) | Extravasation (increased perfusion and vessel permeability) |