Outcome Prediction Using Different Reference Backgrounds for PET Interpretation at 2 Cycles of Chemotherapy
| PFS (population n = 92, events n = 29) | OS (population n = 92, deaths n = 21) | |||||||||
| Parameter | Se | Sp | PPV | NPV | Acc | Se | Sp | PPV | NPV | Acc |
| MBP as reference background | ||||||||||
| >125% SUVmean | 82.8 | 11.1 | 30.0 | 58.3 | 33.7 | 90.5 | 14.1 | 23.8 | 83.3 | 31.5 |
| >221% SUVmean | 51.7 | 71.4 | 45.5 | 76.3 | 65.2 | 61.9 | 71.8 | 39.4 | 86.4 | 69.6 |
| >125% SUVmax | 62.1 | 47.6 | 35.3 | 73.2 | 52.2 | 76.2 | 50.7 | 31.4 | 87.8 | 56.5 |
| >168% SUVmax | 51.7 | 79.4 | 53.6 | 78.1 | 70.7 | 57.1 | 77.5 | 42.9 | 85.9 | 72.8 |
| Liver as reference background | ||||||||||
| >125% SUVmean | 79.3 | 28.6 | 33.8 | 75.0 | 44.6 | 85.7 | 29.6 | 26.5 | 87.5 | 42.4 |
| >201% SUVmean | 55.2 | 76.2 | 51.6 | 78.7 | 69.6 | 61.9 | 74.6 | 41.9 | 86.9 | 71.7 |
| >125% SUVmax | 58.6 | 71.4 | 48.6 | 78.9 | 67.4 | 66.7 | 70.4 | 40.0 | 87.7 | 69.6 |
| >140% SUVmax | 58.6 | 79.4 | 56.7 | 80.6 | 72.8 | 66.7 | 77.5 | 46.7 | 88.7 | 75.0 |
Se = sensitivity; Sp = specificity; PPV = positive predictive value; NPV = negative predictive value; Acc = accuracy.
Data are percentages.