TABLE 2.

Biodistribution Results for ¹⁷⁷Lu-AM3 in Nude Mice Bearing HEK-sst₂ and HEK-sst₃ Tumors

	Biodistribution (h)
Organ	1	4	4, tumor blocking^*	4, kidney blocking^†	24
Blood	0.28 ± 0.20	0.01 ± 0.00	0.01 ± 0.01	0.02 ± 0.01	0.01 ± 0.01
Heart	0.15 ± 0.03	0.01 ± 0.01	0.02 ± 0.01	0.02 ± 0.01	0.02 ± 0.01
Liver	0.70 ± 0.05	0.48 ± 0.08	0.52 ± 0.10	0.46 ± 0.08	0.35 ± 0.10
Spleen	0.24 ± 0.06	0.11 ± 0.01	0.12 ± 0.04	0.12 ± 0.02	0.10 ± 0.04
Lung	0.64 ± 0.07	0.16 ± 0.02	0.16 ± 0.06	0.13 ± 0.02	0.09 ± 0.06
Kidney	7.81 ± 0.24	5.09 ± 1.10	5.66 ± 0.45	2.61 ± 0.59	3.00 ± 0.45
Stomach	0.51 ± 0.04	0.21 ± 0.02	0.05 ± 0.03	0.18 ± 0.05	0.11 ± 0.03
Intestine	0.18 ± 0.02	0.06 ± 0.03	0.08 ± 0.02	0.06 ± 0.01	0.03 ± 0.02
Adrenal	0.21 ± 0.02	0.02 ± 0.02	0.15 ± 0.08	0.18 ± 0.06	0.07 ± 0.02
Pancreas	0.18 ± 0.02	0.05 ± 0.03	0.03 ± 0.00	0.07 ± 0.01	0.04 ± 0.00
Pituitary	0.75 ± 0.15	0.31 ± 0.06	0.19 ± 0.06	0.32 ± 0.17	0.03 ± 0.06
Muscle	0.06 ± 0.03	0.01 ± 0.01	0.03 ± 0.02	0.01 ± 0.01	0.02 ± 0.01
Bone	0.28 ± 0.06	0.07 ± 0.04	0.05 ± 0.01	0.15 ± 0.05	0.15 ± 0.05
sst₂ tumor	10.37 ± 0.76	6.05 ± 1.13	1.82 ± 0.66	4.94 ± 1.45	2.33 ± 0.66
sst₃ tumor	12.74 ± 0.75	7.56 ± 2.16	0.37 ± 0.07	6.24 ± 1.30	3.61 ± 0.74

↵* Tumor blocking: coinjection of 2,000-fold excess of DOTANOC.
↵† Kidney blocking: 10-min preinjection of 20 mg of lysin/100 μL.
Data are %ID/g ± SD, n = 4–7.