TABLE 2

¹⁸F-FDG PET and ¹⁸F-FDG PET/CT in Early Assessment of Response to Therapy for Esophageal Cancer

Tumor type	Authors	Year	n	Criteria for response on PET	Outcome measure	Design	Hazard ratio	P
AEG	Weber et al. (28)	2001	37	35% mean SUV decrease	Median overall survival	Retrospective	NL	0.04
SCC^*	Wieder et al. (30)	2004	23	30% mean SUV decrease	Median overall survival	Retrospective	NL	0.011
AEG	Ott et al. (34)	2006	65	35% mean SUV decrease	Median overall survival	Prospective	0.22^†	0.018^†
AEG	Lordick et al. (35)	2007	110	35% mean SUV decrease	Median event-free survival	Prospective	2.18	0.002
SCC and AEG^*	Gillham et al. (31)	2006	32	20% mean SUV decrease^‡	Prediction of tumor regression grade	Prospective	NA	NS

↵* Chemoradiation; otherwise, only chemotherapy.
↵† Subgroup of patients with complete resection (n = 41).
↵‡ After 1 wk; otherwise, after 2 wk.
AEG = adenocarcinoma of esophagogastric junction; NL = not listed; NA = not applicable; NS = not significant.