Summary of Published Data: Patients
| Study | No. of patients | Primary site | Study purpose | Patient characteristics | Heminecks | P/R | Mode of treatment | Stage | Median age (y) |
|---|---|---|---|---|---|---|---|---|---|
| Yao (66) | 85 | 79% OP, OC, La | Res dz after defin or postop RT? | Defin or postop RT | NA | R | 58 defin (C)RT (70–74 Gy); 27 postop RT (60–66 Gy); all IMRT | No data | No data |
| McColumn (132) | 40 | 88% OP, OC, La | Assess primary after induction chemo; assess neck after defin CRT | Induction chemo, followed by CRT | NA | R | CRT (70 Gy) | 3–4 | 54 |
| Ware (133) | 53 | 74% OC, OP, La | Any res dz? | Res structural abnormality (9% postop; 15% op + RT; 15% RT only; 55% CRT; 6% induction chemo) | NA | R | Mixed; see patient characteristics | 1–4 | No data |
| Yao (75) | 53 | 81% OP, La | Res neck dz? | Defin (C)RT, cpl response at primary | 70 | R | Defin (C)RT; 45 with IMRT | 2–4 | 53 |
| Porceddu (74) | 39 | 92% OP, La | Res neck dz? | Res neck mass 8 wk after (C)RT | 50 | R | Defin (C)RT, chemo in 35/29 | 3–4 | 55 |
| Brkovich (134) | 19 | No data | Res neck dz? | Cpl response at primary site | 21 | P | (C)RT, no details | 3–4 | 58 |
| Andrade* (68) | 28 | 85% OC, OC, La | Any persistent locoregional dz? | 28 consecutive pts after defin (C)RT | NA | R | CRT (58–80 Gy), all IMRT | 2–4 | 58 |
| Gourin* (69) | 17 | All OP or La | Res neck dz? | Cpl response at primary site; planned ND | NA | R | CRT (68–72 Gy) | 4 | 53 |
| Nayak* (70) | 43 | 95% OC, OP, La | Res neck dz? | N2–3 dz after CRT (details unknown in 5; some pts also had brachy- or molecular therapy) | Not reported | R | CRT (64 ± 11 Gy; median, 68); 14 had IMRT | 4 | No details |
| Tan (135) | 48 | 90% OP, La | Res neck dz? | Defin CRT | 72 | R | CRT (66–72 Gy) | 4 | No data |
| Yao (136) | 188 | 85% OC, OP, La | Res dz primary or neck? | PET within 12 mo after RT (128 defin (C)RT; 60 postop) | NA | R | 128 defin (96 CRT, 32 RT only); 60 postop (4 CRT; 56 RT only) | 1–4 | 57 |
| Ong* (67) | 65 | 89% OP, La | Res neck dz? | Defin CRT | 84 | R | CRT (66–72 Gy) | 3–4 | 57 |
↵* All patients underwent PET/CT.
(C) = chemo-; chemo = chemotherapy; cpl = complete; CRT = chemoradiotherapy; defin = definitive; dz = disease; IMRT = intensity-modulated radiotherapy; La = larynx; NA = not applicable; ND = neck dissection; OC = oral cavity; op = operation; OP = oropharynx; P = prospective; postop = postoperative; pts = patients; R = retrospective; res = residual; RT = radiotherapy.