18F-FDG PET for Detection of Recurrence of Ovarian Carcinoma
| Author | Year | Number of patients | Modality | Sens | Spec | Acc | PPV | NPV | Design | Change of management |
|---|---|---|---|---|---|---|---|---|---|---|
| Smith (57) | 1999 | Simulation study | PET | NA | NA | NA | NA | NA | Simulation analysis of cost with and without PET | Decrease of unnecessary surgery from 70% to 5% |
| Bristow (51) | 2003 | 22 with rising CA-125 and equivocal CT | PET/CT for detection of tumor > 1 cm | 83% | NA | 82% | 94% | Prospective study | Complete cytoreduction to no gross residual tumor: 72% | |
| Havrilesky (47) | 2005 | 10 studies between 1966 and 2003 | PET | 90% | 86% | NA | NA | NA | Review | NA |
| CT | 68% | 58% | ||||||||
| PET when CA-125 high | 94% | 80% | NA | NA | NA | NA | ||||
| PET when CA-125 normal | 54% | 73% | NA | NA | NA | NA | ||||
| Ruiz (49) | 2005 | 17 studies between 1972 and 2003 | PET | 94% | 65% | NA | NA | NA | Metaanalysis | NA |
| Simcock (52) | 2006 | 55 for surveillance or suspicion of relapse | PET/CT | NA | NA | NA | NA | NA | Prospective | 58% |
| Garcia (50) | 2007 | 80 for suspicion of relapse | PET | 87% | 79% | 85% | 92% | 68% | Retrospective study | NA |
| CT | 53% | 82% | 61% | 89% | 39% | |||||
| CA-125 | 58% | 94% | 67% | |||||||
| Mangili (53) | 2007 | 32 for suspicion of relapse | PET/CT; CT | NA | NA | NA | NA | NA | Retrospective study | 44% |
| Chung (54) | 2007 | 77 | PET/CT | 93% | 97% | 94% | 98% | 91% | Retrospective study | 25% |
| Kitajama (56) | 2008 | 132 | PET/contrast-enhanced CT | 79% | 91% | 85% | NA | NA | Retrospective study | 39% |
| PET/unenhanced CT | 74% | 91 | 83% | NA | NA | NA | ||||
| Contrast-enhanced CT | 61% | 85% | 73% | NA | NA | NA | ||||
| Soussan (55) | 2008 | 29 | PET/CT | NA | NA | NA | NA | NA | Questionnaire | 33% |
Sens = sensitivity; Spec = specificity; Acc = accuracy; PPV = positive-predictive value; NPV = negative-predictive value; NA = not available.