Response Monitoring After Local Ablative Therapy for Treatment of Colorectal Cancer Liver Metastases
| Authors | Year | Reference | No. of patients | Therapy | Timing of PET evaluation | PET response criteria | Outcome measures | Results |
|---|---|---|---|---|---|---|---|---|
| Langenhoff et al. | 2002 | 26 | 22 | CSA and RFA | <3 wk | Negative results | Recurrence | NPV 100%; PPV 80% |
| Donckier et al. | 2003 | 28 | 17 | RFA | 1 wk, 4 wk | Negative results | Residual tumor | NPV 100%; PPV 100% |
| Joosten et al. | 2005 | 27 | 43 | CSA and RFA | <3 wk | Negative results | Recurrence | NPV 97%; PPV 88% |
| Veit et al. | 2006 | 30 | 11 | RFA | <2 d | Negative results | Recurrence | Accuracy 68% |
| Denecke et al. | 2007 | 20 | 21 | LITT | 1–3 d, 1–6 mo, >6 mo | Negative results | Residual tumor or recurrence | NPV 96%; PPV 97% |
CSA = cryosurgical ablation; RFA = radiofrequency ablation; NPV = negative predictive value; PPV = positive predictive value; LITT = laser-induced thermotherapy.