TABLE 1

Demographic and Clinical Characteristics of 3 Diagnostic Groups

Characteristic	Control	MCI	AD
n	10	12	15
Age (y)^*	70 ± 6	68 ± 9	63 ± 7
Sex (F/M)	3/7	2/10	6/9
MMSE^†	29 ± 1	28 ± 2	24 ± 2^‡^§
Aβ_1–42 (pg/mL)^†	886 ± 244	623 ± 165^§	507 ± 78^§
Tau (pg/mL)^†	264 ± 104	431 ± 269	752 ± 371^§^\|\|
¹¹C-PiB BP_ND
Global^†	0.18 ± 0.30	0.33 ± 0.37	0.86 ± 0.12^‡^§
Frontal	0.22 ± 0.37	0.37 ± 0.42	0.93 ± 0.11^‡^§
Medial temporal	0.08 ± 0.08	0.07 ± 0.06	0.15 ± 0.09^\|\|^¶
Temporal	0.16 ± 0.27	0.31 ± 0.34	0.79 ± 0.11^‡^§
Posterior cingulate	0.17 ± 0.22	0.37 ± 0.38	0.84 ± 0.41^‡^§
Parietal	0.17 ± 0.30	0.34 ± 0.21	0.96 ± 0.20^‡^§
¹⁸F-FDDNP BP_ND
Global^*	0.06 ± 0.03	0.08 ± 0.05	0.09 ± 0.02
Frontal^*	0.05 ± 0.04	0.09 ± 0.06	0.09 ± 0.02
Medial temporal	0.12 ± 0.04	0.13 ± 0.05	0.14 ± 0.05
Temporal	0.07 ± 0.03	0.10 ± 0.05	0.10 ± 0.03
Posterior cingulate	0.04 ± 0.01	0.07 ± 0.02	0.06 ± 0.01
Parietal	0.02 ± 0.04	0.04 ± 0.04	0.06 ± 0.03

ANOVA with age as covariate:
↵* P < 0.10.
↵† P ≤ 0.001.
Post hoc least-significant difference tests:
↵‡ P ≤ 0.001, compared with MCI.
↵§ P ≤ 0.001, compared with controls.
↵|| P < 0.05, compared with MCI.
↵¶ P < 0.05, compared with controls.
Data are mean ± SD, where appropriate. Note that raw values are shown for CSF biomarkers (pg/mL) but that log-transformed values were used for statistical analysis.
MMSE = Mini-Mental State Examination.