TABLE 4

Correlations Between Neuropsychologic Measures and Regional nAChR Availability

		Correlations (r) for following brain regions:
Group	Neuropsychologic measure	PC	FC	AC	TC	OC	Thalamus
HC	Boston Naming Test	0.39	0.43	0.54	0.42	0.36	0.50
	Category Fluency	NA	0.43	0.55	0.51	NA	0.34
	Letter Fluency (FAS)	NA	0.43	0.59	0.66^*	NA	0.44
	Trail Making Test, Part A^†	−0.66^*	−0.55	−0.59	−0.50	−0.46	−0.32
	Trail Making Test, Part B^†	−0.61	−0.78^‡	−0.91^§	−0.72^*	−0.61	−0.77^‡
	Digit Symbol Test (WAIS-III)	0.59	0.65^*	0.75^*	0.64^*	0.61	0.72^*
	Stroop Color-Word score	0.33	0.08	0.16	0.25	0.31	0.19
	NYU Paragraph, delayed	NA	0.11	0.11	0.17	NA	0.18
	Visual Reproductions II	0.51	0.64^*	0.58	0.60	0.52	0.58
	Block Design (WAIS-III)	0.18	0.24	0.47	0.30	0.13	0.17
MCI	Boston Naming Test	−0.11	0.10	0.52	0.52	0.34	0.27
	Category Fluency	NA	−0.11	0.13	0.19	NA	0.15
	Letter Fluency (FAS)	NA	−0.29	−0.13	−0.09	NA	−0.32
	Trail Making Test, Part A^†	−0.13	−0.23	−0.31	−0.34	−0.40	−0.58
	Trail Making Test, Part B^†	0.13	0.10	0.06	−0.13	−0.18	−0.32
	Digit Symbol Test (WAIS-III)	0.07	0.09	0.18	0.21	0.14	0.12
	Stroop Color-Word score	−0.55	−0.25	−0.09	0.00	−0.18	−0.07
	NYU Paragraph, delayed	NA	0.16	0.32	0.37	NA	0.27
	Visual Reproductions II	0.37	0.23	0.56	0.70^*	0.72^*	0.56
	Block Design (WAIS-III)	−0.43	−0.29	−0.13	−0.02	−0.12	−0.08
AD	Boston Naming Test	0.11	0.35	0.50	0.44	0.43	0.39
	Category Fluency	NA	0.61^*	0.61^*	0.54	NA	0.62^*
	Letter Fluency (FAS)	NA	0.26	0.28	0.28	NA	0.34
	Trail Making Test, Part A^†	0.37	0.32	0.32	0.34	0.26	0.27
	Trail Making Test, Part B^†	0.02	0.02	−0.03	0.07	−0.04	−0.03
	Digit Symbol Test (WAIS-III)	−0.13	−0.07	−0.03	−0.08	−0.03	−0.01
	Stroop Color-Word score	0.17	0.05	0.21	0.15	0.30	0.15
	NYU Paragraph, delayed	NA	−0.19	−0.13	−0.13	NA	−0.14
	Visual Reproductions II	0.34	0.07	0.08	0.17	0.32	0.09
	Block Design (WAIS-III)	−0.03	−0.10	−0.04	−0.06	0.09	0.02

↵* P<0.05.
↵† Measure for which lower score indicates better performance.
↵‡ P<0.01.
↵§ P<0.001.
PC = parietal cortex; FC = frontal cortex; AC = anterior cingulate; TC = temporal cortex; OC = occipital cortex; NA = not applicable because region was not primarily related to cognitive task; FAS = Controlled Oral Word Association Test, Letters F-A-S; WAIS-III = Wechsler Adult Intelligence Scale, third edition; Visual Reproductions II was from Wechsler Memory Scale, third edition.
Correlations were determined with unscaled test scores. Bold type indicates significant correlation (P < 0.05).