Effect of Diagnostic Group on Regional α4β2-nAChR Availability (VT)
| VT values for subjects in the following groups: | ||||||||
|---|---|---|---|---|---|---|---|---|
| HC (n = 10) | MCI (n = 10) | AD (n = 12) | ||||||
| Brain region | Mean | SD | Mean | SD | Mean | SD | F2,27 | P |
| Thalamus | 41.7 | 7.7 | 38.3 | 7.3 | 37.7 | 7.8 | 0.53 | 0.593 |
| Frontal cortex | 15.6 | 2.8 | 14.9 | 2.6 | 15.9 | 3.7 | 0.39 | 0.681 |
| Parietal cortex | 15.1 | 2.7 | 13.4 | 2.0 | 14.1 | 3.1 | 0.85 | 0.439 |
| Anterior cingulate | 16.9 | 3.6 | 16.1 | 2.6 | 16.0 | 3.9 | 0.09 | 0.914 |
| Temporal cortex | 19.1 | 3.3 | 18.1 | 2.5 | 17.7 | 3.8 | 0.27 | 0.767 |
| Striatum | 23.2 | 3.9 | 21.3 | 3.3 | 21.0 | 5.4 | 0.48 | 0.624 |
| Occipital cortex | 17.2 | 2.9 | 16.4 | 2.2 | 16.0 | 3.0 | 0.27 | 0.767 |
| Cerebellum | 21.6 | 3.8 | 20.1 | 4.9 | 20.7 | 4.4 | 0.30 | 0.741 |
MANCOVA revealed significant overall group difference in mean VT (F16,40 = 2.25; P = 0.019), controlling for age and sex. F and P values were from post hoc univariate analyses of each brain region, controlling for age and sex.