Summary of Previous Studies
| P1 | P2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reference | n* | GR/PR | P | Mean | Median | Range | Mean | Median | Range | Cutoff† | PPV | NPV |
| Schulte et al. (7) | 27 | 17/10 | TBR | 10.3 | 3.3–33.2 | 2.92 | 0.32–20.33 | P2/P1 ≤ 0.6 for GR (n = 19) | 89.5% | 100% | ||
| Franzius et al. (13) | 11 | 9/2 | TBR | 4.4 | 2.3–13.6 | 1.7 | 0.9–11.9 | P2/P1 < 0.7 for GR (n = 9) | 100% | 100% | ||
| Ye et al. (16) | 15 | 8/7 | TBR | 7.1 | 3.0–20.6 | 3.1 | 1.1–6.5 | P2/P1 < 0.46 for GR (n = 8) | 100% | 100% | ||
| Hawkins et at. (14) | 18 | 5/13 | SUVmax | 8.2 | 2.5–24.1 | 3.3 | 1.6–12.8 | P2 < 2 for GR (n = 4) | 75% | 85.7% | ||
| Huang et al. (15) | 10 | 2/8 | SUVmax | 8.2 | 1.4–13.6 | 4.4 | 1.7–9.6 | P2/P1 < 0.4 for GR (n = 2) | 100% | 100% | ||
| Present study | 70 | 33/37 | SUVmax | 8.0 | 2.4–47.5 | 4.5 | 1.5–16.6 | Algorithm for GR (n = 32) | 97% | 95% | ||
↵* Patients with high-grade osteosarcoma were included in this table.
↵† n = number of patients who met cutoff criteria.
GR = good responder; PR = poor responder; P = parameter; P1 = parameter before chemotherapy; P2 = parameter after chemotherapy; PPV = positive predictive value; NPV = negative predictive value; TBR = tumor-to-background ratio.