TABLE 2

Verapamil Model Parameters in Human Brain

Model/input	K₁ (mL/g/min)	K₁/k₂ (1/min)	k₃ (1/min)	k₄ (1/min)	Vd_Tot (mL/g)	Ki (mL/g/min)	k₂ (1/min)	Vd (1/min)	Vd_Logan (mL/g)
2C,4P: ver^*
Pre-CsA mean	0.064	0.39	0.127	0.054	1.28	0.027
Pre-CsA range	0.039–0.089	0.235–0.807	0.092–0.179	0.035–0.069	0.68–2.16	0.016–0.039
Post-CsA mean	0.109	0.45	0.255	0.064	2.00	0.051
Post-CsA range	0.064–0.159	0.256–0.774	0.109–0.47	0.042–0.089	1.42–2.88	0.034–0.088
Change (%)	73	27	103	25	67	97
P	0.001	0.329	0.006	0.036	0.001	0.001
1C,2P: ver^†
Pre-CsA mean	0.06						0.106	0.59
Pre-CsA range	0.038–0.081						0.058–0.166	0.35–0.94
Post-CsA mean	0.099						0.097	0.98
Post-CsA range	0.056–0.135						0.073–0.119	0.63–1.53
Change (%)	69						−3	70
P	0.001						0.552	0.003
Logan plot: C_B^*
Pre-CsA man									0.76
Pre-CsArange									0.53–0.96
Post-CsA mean									1.46
Post-CsA range									1.0–1.87
Change (%)									93
P									0.001

↵* 45 min of data.
↵† 10 min of data.
Vd_Tot = (K₁/k₂) + [(K₁ × k₃)/(k₂ × k₄)]; Vd = (K₁/k₂); Vd_Logan = (k₃/k₄); Ki = (K₁ × k₃)/(k₂ + k₃). 2C,4P = 2-compartment, 4-parameter model; 1C,2P = 1-compartment, 2-parameter model; ver = verapamil model input function.