Effect of POS Concentration on Biodistribution of 125I-IPOS in FM3A-Implanted Mice at 24 Hours After Injection
| Protein concentration (μg) | ||||
|---|---|---|---|---|
| Organ | 0.05 | 0.5 | 5 | 30 |
| Blood | 0.12 ± 0.04 | 0.16 ± 0.10 | 0.16 ± 0.01 | 0.27 ± 0.07 |
| Liver | 1.92 ± 0.24 | 1.27 ± 0.53 | 5.53 ± 1.05 | 13.61 ± 1.90 |
| Spleen | 1.07 ± 0.30 | 1.15 ± 0.41 | 2.33 ± 0.25 | 7.87 ± 2.20 |
| Kidney | 0.35 ± 0.20 | 0.59 ± 0.51 | 1.03 ± 0.10 | 4.32 ± 1.87 |
| Stomach | 0.28 ± 0.14 | 0.55 ± 0.42 | 0.52 ± 0.20 | 0.86 ± 0.27 |
| Neck | 0.05 ± 0.04 | 0.09 ± 0.04 | 0.11 ± 0.02 | 0.23 ± 0.08 |
| Intestine | 4.57 ± 0.82 | 1.95 ± 2.03 | 2.17 ± 0.24 | 2.18 ± 0.28 |
| Tumor | 0.23 ± 0.08 | 0.25 ± 0.07 | 0.49 ± 0.09 | 1.37 ± 0.33 |
| Muscle | 0.05 ± 0.03 | 0.05 ± 0.05 | 0.07 ± 0.01 | 0.10 ± 0.03 |
| Tumor/blood | 2.04 ± 0.61 | 1.61 ± 0.10 | 3.00 ± 0.68 | 5.14 ± 0.34 |
Organ uptake values are expressed as %ID/g of tissue except for tumor/blood. Values are mean ± SD; n = 5.