TABLE 2

Histamine H₁ Receptor BP_ND of ¹¹C-Doxepine for the Various Regions Measured with PET at Baseline and After Administration of 5 mg of Olopatadine in Acute and Chronic Scans

	BP_ND
Region	Baseline	Acute (0 wk)	Chronic (4 wk)	Acute scan receptor occupancy
DLPFC	0.28 ± 0.06	0.24 ± 0.07	0.13 ± 0.08^*	15% ± 15%
Frontobasal	0.33 ± 0.08	0.27 ± 0.07^†	0.15 ± 0.08^*	18% ± 15%
Parietal	0.25 ± 0.05	0.20 ± 0.08	0.09 ± 0.08^*	24% ± 24%
Temporal	0.37 ± 0.07	0.33 ± 0.08	0.21 ± 0.09^*	11% ± 12%
Occipital	0.19 ± 0.04	0.16 ± 0.06	0.09 ± 0.05^*	19% ± 22%
Anterior cingulate	0.29 ± 0.07	0.26 ± 0.07	0.13 ± 0.09^*	14% ± 14%
Thalamus	0.26 ± 0.07	0.18 ± 0.06^†	0.20 ± 0.06	26% ± 20%

↵† P < 0.05/7 in comparison between baseline and acute scan by 2-way ANOVA.
↵* P < 0.01/7 in comparison between acute scan and chronic scan by 2-way ANOVA.
Data are mean ± SD (n = 14). Receptor occupancy was computed as percentage decrease in BP_ND at time of acute scan, compared with baseline.