Reference Tissue Parametric Image Data (Without Outliers)
| Pharmacokinetic parameter | HRRT reconstruction method | Unfixed intercept | Fixed intercept to origin | |||
|---|---|---|---|---|---|---|
| Slope | Intercept | r | Slope | r | ||
| RLogan DVR | 3D-FBP | 0.71 ± 0.15 | 0.90 ± 0.48 | 0.94 ± 0.02 | 0.89 ± 0.07 | 0.76 ± 0.22 |
| 3D-FBP G6 | 0.90 ± 0.13 | 0.20 ± 0.39 | 0.98 ± 0.01 | 0.94 ± 0.10 | 0.95 ± 0.02 | |
| 3D-OSWLS | 0.96 ± 0.15 | 0.23 ± 0.38 | 0.97 ± 0.01 | 1.01 ± 0.11 | 0.93 ± 0.04 | |
| 3D-OSWLS G6 | 0.90 ± 0.13 | 0.17 ± 0.29 | 0.98 ± 0.00 | 0.93 ± 0.11 | 0.96 ± 0.01 | |
| RPM BPND | 3D-FBP | 0.84 ± 0.18 | 0.85 ± 0.35 | 0.97 ± 0.01 | 1.04 ± 0.14 | 0.83 ± 0.15 |
| 3D-FBP G6 | 0.92 ± 0.14 | 0.09 ± 0.28 | 0.98 ± 0.00 | 0.94 ± 0.13 | 0.96 ± 0.01 | |
| 3D-OSWLS | 1.01 ± 0.23 | 0.29 ± 0.28 | 0.98 ± 0.01 | 1.08 ± 0.19 | 0.94 ± 0.03 | |
| 3D-OSWLS G6 | 0.92 ± 0.19 | 0.04 ± 0.25 | 0.98 ± 0.00 | 0.93 ± 0.15 | 0.97 ± 0.01 | |
G6 = 6-mm FWHM gaussian kernel.
Slope, intercept, and r (all data are mean ± SD) of reference tissue (pons) kinetic data using HRRT- vs. HR+-reconstructed scans of 4 subjects for 3D-FBP and 5 subjects for 3D-OSWLS, over various ROIs.