Reference Tissue Kinetic Data Using Time–Activity Curve Analysis (with Outliers)
| Pharmacokinetic parameter | HRRT reconstruction method | Unfixed intercept | Fixed intercept to origin | |||
|---|---|---|---|---|---|---|
| Slope | Intercept | r | Slope | r | ||
| RLogan DVR | 3D-FBP | 1.10 ± 0.51 | 0.02 ± 0.51 | 0.97 ± 0.01 | 1.10 ± 0.44 | 0.97 ± 0.01 |
| 3D-FBP G6 | 0.99 ± 0.43 | 0.06 ± 0.44 | 0.98 ± 0.00 | 1.00 ± 0.37 | 0.98 ± 0.01 | |
| 3D-OSWLS | 0.98 ± 0.24 | 0.01 ± 0.27 | 0.98 ± 0.01 | 0.98 ± 0.22 | 0.98 ± 0.01 | |
| 3D-OSWLS G6 | 0.85 ± 0.20 | 0.10 ± 0.21 | 0.98 ± 0.00 | 0.87 ± 0.18 | 0.98 ± 0.00 | |
| RPM BPND | 3D-FBP | 1.11 ± 0.56 | 0.11 ± 0.23 | 0.97 ± 0.01 | 1.14 ± 0.54 | 0.97 ± 0.01 |
| 3D-FBP G6 | 0.96 ± 0.45 | 0.16 ± 0.38 | 0.97 ± 0.02 | 1.00 ± 0.44 | 0.96 ± 0.05 | |
| 3D-OSWLS | 1.00 ± 0.25 | −0.05 ± 0.46 | 0.98 ± 0.01 | 0.99 ± 0.25 | 0.97 ± 0.01 | |
| 3D-OSWLS G6 | 0.86 ± 0.20 | −0.05 ± 0.29 | 0.98 ± 0.00 | 0.85 ± 0.20 | 0.98 ± 0.01 | |
G6 = 6-mm FWHM gaussian kernel.
Slope, intercept, and r (all data are mean ± SD) of reference tissue (pons) kinetic data using HRRT- vs. HR+-reconstructed scans of 6 subjects, over various ROIs.