Plasma Input Kinetic Data Using Time–Activity Curve Analysis
| Pharmacokinetic parameter | HRRT reconstruction method | Unfixed intercept | Fixed intercept to origin | |||
|---|---|---|---|---|---|---|
| Slope | Intercept | r | Slope | r | ||
| Logan VT | 3D-FBP | 1.15 ± 0.05 | 0.19 ± 0.43 | 0.97 ± 0.01 | 1.19 ± 0.10 | 0.97 ± 0.01 |
| 3D-FBP G6 | 1.03 ± 0.07 | 0.20 ± 0.34 | 0.98 ± 0.00 | 1.07 ± 0.11 | 0.98 ± 0.01 | |
| 3D-OSWLS | 1.15 ± 0.05 | −0.03 ± 0.32 | 0.98 ± 0.00 | 1.14 ± 0.10 | 0.98 ± 0.00 | |
| 3D-OSWLS G6 | 1.02 ± 0.07 | 0.09 ± 0.27 | 0.98 ± 0.00 | 1.04 ± 0.11 | 0.98 ± 0.00 | |
| BFM VT | 3D-FBP | 0.99 ± 0.21 | 1.21 ± 0.35 | 0.93 ± 0.03 | 1.29 ± 0.23 | 0.88 ± 0.05 |
| 3D-FBP G6 | 1.08 ± 0.17 | −0.16 ± 0.32 | 0.98 ± 0.01 | 1.04 ± 0.22 | 0.98 ± 0.01 | |
| 3D-OSWLS | 1.14 ± 0.17 | −0.13 ± 0.45 | 0.98 ± 0.01 | 1.11 ± 0.22 | 0.97 ± 0.00 | |
| 3D-OSWLS G6 | 1.08 ± 0.18 | −0.28 ± 0.28 | 0.98 ± 0.00 | 1.00 ± 0.21 | 0.98 ± 0.00 | |
G6 = 6-mm FWHM gaussian kernel.
Slope, intercept, and r (all data are mean ± SD) of plasma input kinetic data using HRRT- vs. HR+-reconstructed scans of 5 subjects, over various ROIs.