Bmax and KD of (R)-Rolipram Measured In Vivo and In Vitro in Regions of Rat Brain
| Bmax (nM) | KD (nM) | |||||
|---|---|---|---|---|---|---|
| In vivo | In vivo | |||||
| Region | Conscious | Anesthetized | In vitro | Conscious | Anesthetized | In vitro |
| Frontal cortex | 68.3 | 64.8 | 84 ± 6 | 1.10 | 0.97 | 5.5 ± 0.3 |
| Hippocampus | 79.7 | 54.3 | 66 ± 6 | 1.57 | 0.73 | 5.4 ± 0.3 |
| Diencephalon | 66.7 | 48.6 | 81 ± 8 | 1.31 | 0.79 | 6.1 ± 0.3 |
Values from in vitro studies are mean ± SD. In vitro KD published in Fujita et al. (13) measured with racemic 3H-rolipram was divided by 2 to calculate KD of (R)-rolipram.