Plasma Input and Reference Tissue Kinetic Data Using Time–Activity Curve Analysis
| Logan VT | RPM BPND | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROI | HRRT (OSWLS) | HRRT G6 (OSWLS) | HRRT (OSWLS) | HRRT G6 (OSWLS) | ||||||||
| Brain area | Side | Volume (mL) | HR+, VT | VT | Absolute variability (%) | VT | Absolute variability (%) | HR+, BPND | BPND | Absolute variability (%) | BPND | Absolute variability (%) |
| Frontal lobe | Left | 12.1 ± 2.6 | 5.3 ± 0.6 | 6.2 ± 0.4 | 15.0 ± 7.1 | 5.5 ± 0.4 | 7.8 ± 6.6 | 4.8 ± 0.9 | 5.4 ± 1.5 | 12.7 ± 8.6 | 4.6 ± 1.2 | 10.0 ± 10.8 |
| Right | 14.8 ± 2.4 | 6.0 ± 0.5 | 6.7 ± 0.5 | 11.6 ± 7.2 | 6.0 ± 0.5 | 7.2 ± 3.5 | 5.4 ± 0.7 | 5.7 ± 1.2 | 10.6 ± 8.2 | 4.8 ± 1.0 | 13.3 ± 14.0 | |
| Temporal lobe | Left | 22.5 ± 4.9 | 5.5 ± 0.3 | 6.0 ± 0.6 | 11.7 ± 3.6 | 5.5 ± 0.6 | 8.7 ± 6.5 | 5.0 ± 0.4 | 5.0 ± 0.8 | 9.1 ± 4.5 | 4.3 ± 0.5 | 15.3 ± 8.3 |
| Right | 21.3 ± 5.8 | 5.9 ± 0.3 | 6.2 ± 0.7 | 9.0 ± 5.0 | 5.7 ± 0.7 | 8.1 ± 7.0 | 5.3 ± 0.4 | 5.0 ± 0.8 | 11.6 ± 6.0 | 4.4 ± 0.5 | 17.7 ± 10.1 | |
| Parietal lobe | Left | 12.8 ± 3.4 | 5.5 ± 0.3 | 6.8 ± 0.6 | 20.1 ± 7.7 | 6.2 ± 0.7 | 10.4 ± 9.3 | 5.0 ± 0.4 | 5.8 ± 1.0 | 17.0 ± 11.5 | 5.0 ± 0.8 | 11.3 ± 8.2 |
| Right | 12.6 ± 3.5 | 5.5 ± 0.5 | 6.2 ± 0.5 | 12.3 ± 7.6 | 5.7 ± 0.6 | 6.8 ± 6.6 | 4.9 ± 0.6 | 5.5 ± 1.4 | 15.4 ± 13.5 | 4.8 ± 1.0 | 13.6 ± 7.4 | |
| Occipital lobe | Left | 18.7 ± 8.6 | 5.9 ± 0.4 | 6.9 ± 0.9 | 15.8 ± 7.2 | 6.2 ± 1.0 | 9.2 ± 4.7 | 5.2 ± 0.2 | 5.6 ± 0.8 | 13.4 ± 8.4 | 4.9 ± 0.5 | 11.1 ± 4.9 |
| Right | 13.7 ± 4.5 | 6.1 ± 0.5 | 7.2 ± 1.1 | 15.6 ± 8.8 | 6.5 ± 1.1 | 10.3 ± 4.5 | 5.3 ± 0.7 | 5.8 ± 0.6 | 14.0 ± 11.9 | 4.9 ± 0.3 | 11.9 ± 5.6 | |
| Thalamus | Left | 2.0 ± 0.9 | 3.3 ± 0.2 | 4.2 ± 0.7 | 21.1 ± 12.2 | 3.7 ± 0.6 | 11.6 ± 10.8 | 2.6 ± 0.3 | 3.3 ± 0.7 | 23.7 ± 13.7 | 2.8 ± 0.5 | 12.0 ± 8.0 |
| Right | 2.3 ± 0.6 | 3.5 ± 0.2 | 4.4 ± 0.6 | 20.1 ± 14.3 | 3.8 ± 0.6 | 13.6 ± 7.3 | 2.8 ± 0.2 | 3.4 ± 0.4 | 18.1 ± 11.2 | 2.8 ± 0.3 | 8.1 ± 5.0 | |
| Caudate | Left | 2.2 ± 0.3 | 2.6 ± 0.3 | 2.8 ± 0.3 | 19.8 ± 23.0 | 2.5 ± 0.3 | 19.1 ± 12.5 | 1.9 ± 0.5 | 2.1 ± 0.8 | 25.6 ± 6.0 | 1.7 ± 0.6 | 20.0 ± 23.0 |
| Right | 2.1 ± 0.3 | 2.8 ± 0.2 | 3.1 ± 0.4 | 17.2 ± 10.9 | 2.8 ± 0.4 | 16.0 ± 12.0 | 2.0 ± 0.3 | 2.4 ± 0.4 | 17.4 ± 10.6 | 1.9 ± 0.3 | 10.4 ± 12.7 | |
| Putamen | Left | 1.6 ± 0.9 | 3.7 ± 0.1 | 4.1 ± 0.5 | 14.6 ± 12.5 | 4.0 ± 0.6 | 13.9 ± 6.2 | 3.1 ± 0.3 | 3.2 ± 0.7 | 11.4 ± 9.6 | 3.0 ± 0.5 | 7.6 ± 12.0 |
| Right | 1.9 ± 0.7 | 3.5 ± 0.3 | 3.9 ± 0.5 | 10.7 ± 9.6 | 3.7 ± 0.5 | 10.2 ± 9.7 | 2.9 ± 0.6 | 3.1 ± 0.7 | 9.0 ± 7.5 | 2.8 ± 0.6 | 9.9 ± 9.8 | |
| Pons | — | 5.5 ± 0.6 | 0.9 ± 0.0 | 0.9 ± 0.2 | 13.7 ± 7.3 | 1.0 ± 0.2 | 13.3 ± 3.8 | — | — | — | — | — |
G6 = 6-mm FWHM gaussian kernel.
Logan VT, RPM BPND, and absolute-variability values (mean ± SD for all values) using HRRT- vs. HR+-reconstructed scans of 5 subjects for various ROIs. Absolute variability (test–retest) is calculated as |HRRT − HR+|/((HRRT + HR+)·0.5)·100%.