Dosage Biodistribution at 32 Hours After Administration of 99mTc-Antisense MORF/tat/Trastuzumab Nanoparticle and 99mTc-Trastuzumab at Same Antibody Dose to SUM190 Tumor–Bearing Mice
| Organ | 99mTc-antisense-MORF/tat/trastuzumab | 99mTc-trastuzumab |
|---|---|---|
| Liver | 10.4 (3.3) | 2.74 (0.35) |
| Heart | 1.58 (0.18) | 1.01 (0.14) |
| Kidneys | 19.7 (1.89) | 6.58 (0.55) |
| Lung | 1.93 (0.30) | 1.37 (0.27) |
| Spleen | 5.09 (1.46) | 2.44 (0.48) |
| Stomach | 0.40 (0.04) | 0.21 (0.02) |
| Small intestine | 0.47 (0.03) | 0.37 (0.06) |
| Large intestine | 0.82 (0.17) | 0.54 (0.05) |
| Muscle | 0.57 (0.08) | 0.24 (0.02) |
| Tumor | 10.45 (2.94) | 12.02 (1.20) |
| Blood | 2.17 (0.55) | 3.11 (0.50) |
Data are mean %ID/g with SD of mean (n = 4).