Percentage of 99mTc in SK-BR-3 Cells and in Nucleus of Cells When Incubated for 3 Hours as Radiolabeled AntiRIα Antisense or Sense MORF and as 3-Component Nanoparticles or Free
| Incubate | % in cells | % in nucleus | Nucleus-to-cytoplasm ratio |
|---|---|---|---|
| 99mTc-antisense free | 0.02 ± 0.001 | 0.01 ± 0.001 | |
| 99mTc-antisense/tat/trastuzumab | 8.20 ± 0.38* | 7.62 ± 0.42* | 13.23 ± 1.53* |
| 99mTc-sense free | 0.018 ± 0.001 | 0.01 ± 0.001 | |
| 99mTc-sense/tat/trastuzumab | 7.20 ± 0.30 | 6.54 ± 0.34 | 9.95 ± 1.26 |
↵* P < 0.05, 99mTc-antisense/tat/trastuzumab vs. 99mTc-sense/tat/trastuzumab.
Values are mean ± SD of mean (n = 3).