TABLE 5

Diagnostic Problems for Breast Cancer

TaskApproach
DetectionMammographic screening
Breast MRI screening in high-risk women
DiagnosisDiagnostic mammography
Breast ultrasound
Breast MRI
(18F-FDG-PET with dedicated devices)
(Breast-specific γ-imaging)
Staging
 Regional lymph nodesSentinel lymph node biopsy
Axillary ultrasound
18F-FDG PET/CT
 Distant metastasesCT, MRI
Bone scintigraphy or fluoride PET
18F-FDG PET/CT
Response
 Neoadjuvant therapyMammography or breast ultrasound
MRI
18F-FDG PET/CT
(Breast sestamibi imaging)
(Magnetic resonance spectroscopy)
 Metastatic therapyCT or MRI
18F-FDG PET/CT
Tumor markers
CharacterizationHistopathology and special assays
(18F-FDG PET/CT)
(Breast sestamibi)
(Molecular imaging)
  • Experimental or less commonly used approaches are in parentheses.