Experimental Parameters and Results of In Vivo Imaging Studies
| Radiotracer (no. of rats) | 11C-PK11195 (n = 5) | 11C-DPA-713 (n = 4) | 11C-DPA-713 (n = 4) | 11C-DPA-713 (n = 4) | 18F-DPA-714 (n = 5) | 18F-DPA-714 (n = 5) | 18F-DPA-714 (n = 4) |
|---|---|---|---|---|---|---|---|
| Weight (g) | 275 ± 50 | 300 ± 10 | 306 ± 7 | 345 ± 38 | 344 ± 26 | 348 ± 32 | 358 ± 14 |
| Temperature (°C) | 36.6 ± 0.8 | 36.9 ± 0.2 | 36.7 ± 0.2 | 36.9 ± 0.2 | 37.0 ± 0.3 | 36.9 ± 0.5 | 36.8 ± 0.1 |
| Injected dose (MBq) | 95.3 ± 15.1 (72.2–110) | 72.4 ± 7.3 (61.9–77.8) | 66.5 ± 6.7 (61.1–75.9) | 77.4 ± 10.1 (69.3–90.7) | 69.3 ± 6.3 (61.3–75.9) | 70.8 ± 9.1 (62.4–85.6) | 70.2 ± 8.3 (65.1–82.5) |
| Specific radioactivity (MBq/nmol) | 30.6 ± 24.2 (3.78–56.9) | 60.9 ± 23.1 (42.2–92.4) | 46.3 ± 5.2 (40.0–51.8) | 55.4 ± 20.1 (38.6–81.4) | 87.9 ± 64.0 (26.5–154) | 37.1 ± 24.8 (8.3–67.4) | 51.4 ± 31.0 (21.8–92.9) |
| Amount of radioligand (nmol) | 8.23 ± 9.41 (1.88–23.7) | 1.33 ± 0.50 (0.67–1.74) | 1.41 ± 0.21 (1.25–1.71) | 1.51 ± 0.47 (1.11–2.07) | 1.27 ± 1.10 (0.40–2.50) | 3.34 ± 2.99 (0.98–8.20) | 1.75 ± 0.95 (0.89–3.00) |
| Mean ratio, ipsilateral/contralateral | 2.27 ± 0.08 | 3.31 ± 0.31 | Displacement by PK11195 after 20 min: 1.2 ± 0.3 mg/kg | Displacement by DPA-713 after 20 min: 1.0 ± 0.1 mg/kg | 4.30 ± 0.30 | Displacement by PK11195 after 20 min: 1.4 ± 0.8 mg/kg | Displacement by DPA-714 after 20 min: 1.0 ± 0.1 mg/kg |
| R1 | 1.10 ± 0.06 | 1.30 ± 0.27 | 1.64 ± 0.27 | ||||
| k2 | 0.30 ± 0.13 | 0.32 ± 0.20 | 0.46 ± 0.32 | ||||
| BP | 1.07 ± 0.21 | 2.19 ± 0.65 | 3.08 ± 0.67 |
R1, k2, and BP are, respectively, ratio of tracer delivery in ipsilateral over contralateral areas, clearance, and BP. Results are expressed as mean ± SD (minimum–maximum values).