Biodistribution of 124I-PIB-ZHER2:342 and 125I-PIB-Trastuzumab After Injection in BALB/C nu/nu Mice Bearing HER2-Expressing NCI-N87 Xenografts
| Biodistribution | |||
|---|---|---|---|
| Location | 6 h | 24 h | 72 h |
| 124I-PIB-ZHER2:342 | |||
| Blood | 0.59 ± 0.05 | 0.09 ± 0.02 | 0.021 ± 0.008 |
| Lung | 0.8 ± 0.2 | 0.5 ± 0.1 | 0.2 ± 0.1 |
| Liver | 0.84 ± 0.09 | 0.20 ± 0.07 | 0.077 ± 0.008 |
| Spleen | 0.9 ± 0.2 | 0.4 ± 0.2 | 0.18 ± 0.05 |
| Stomach | 1 ± 1 | 0.32 ± 0.09 | 0.14 ± 0.07 |
| Kidney | 3.2 ± 0.4 | 0.19 ± 0.01 | 0.11 ± 0.02 |
| Salivary gland | 0.8 ± 0.3 | NM | NM |
| Thyroid* | 0.2 ± 0.2 | NM | NM |
| Tumor | 4.7 ± 1.0 | 1.4 ± 0.3 | 0.4 ± 0.1 |
| Muscle | 0.10 ± 0.05 | NM | NM |
| Intestines with content* | 1.3 ± 0.22 | 0.07 ± 0.01 | 0.05 ± 0.02 |
| Carcass* | 2.4 ± 0.1 | 0.7 ± 0.1 | 0.17 ± 0.02 |
| 125I-PIB-trastuzumab | |||
| Blood | 18 ± 3 | 13 ± 2 | 9 ± 2 |
| Lung | 6.5 ± 1.0 | 5. 6 ± 0.9 | 3.3 ± 0.6 |
| Liver | 4.7 ± 0.3 | 3.1 ± 0.6 | 1.9 ± 0.6 |
| Spleen | 6 ± 1 | 5 ± 2 | 1.8 ± 0.6 |
| Stomach | 1.5 ± 0.6 | 1.3 ± 0.4 | 0.8 ± 0.3 |
| Kidney | 6.5 ± 1.0 | 5.1 ± 0.3 | 3.0 ± 0.5 |
| Salivary gland | 2.3 ± 0.4 | 2.8 ± 0.5 | 1.7 ± 0.5 |
| Thyroid* | 0.08 ± 0.02 | 0.16 ± 0.06 | 0.041 ± 0.006 |
| Tumor | 14 ± 7 | 16 ± 3 | 12 ± 3 |
| Muscle | 0.7 ± 0.1 | 1.3 ± 0.1 | 0.62 ± 0.08 |
| Intestines with content* | 4.0 ± 0.6 | 2.7 ± 0.2 | 1.7 ± 0.4 |
| Carcass* | 20 ± 3 | 21.0 ± 0.7 | 15 ± 4 |
↵* Data for thyroid, intestines with content, and carcass are given as %IA per whole sample.
NM = nonmeasurable (counts per sample were less than 2 times background counts).
Data are presented as an average %IA/g and SD (n = 4).