TABLE 3

Biodistribution of ¹¹¹In-Bz-DTPA-Z_EGFR:1907 and ¹¹¹In-Bz DTPA-(Z_EGFR:1907)₂ (Injected Dose, 50 μg) 4 and 24 Hours After Injection in BALB/c nu/nu Mice Bearing EGFR-Expressing A431 Xenografts

	4 h after injection		24 h after injection
Organ or tissue	¹¹¹In-Bz-DTPA-Z_EGFR:1907	¹¹¹In-Bz-DTPA-(Z_EGFR:1907)₂	¹¹¹In-Bz-DTPA-Z_EGFR:1907	¹¹¹In-Bz-DTPA-(Z_EGFR:1907)₂
Blood	0.23 ± 0.05^*	0.18 ± 0.03^*	0.025 ± 0.006^*	0.038 ± 009^*
Lung	0.34 ± 0.03^*^†	0.68 ± 0.09^*	0.14 ± 0.03^*^†	0.33 ± 0.06
Liver	1.5 ± 0.2^*^†	6.9 ± 1.2^*	0.7 ± 0.1^*^†	3.6 ± 1.4
Spleen	0.34 ± 0.02^*^†	1.5 ± 0.2	0.29 ± 0.02^†	1.0 ± 0.3
Colon	0.45 ± 0.01^*^†	1.2 ± 0.2	0.22 ± 0.02^*^†	0.6 ± 0.1^*
Kidney	196 ± 4^*	169 ± 32^*	120 ± 10^*	118 ± 14^*
Tumor	3.35 ± 0.08^*^†	2.43 ± 0.35^*	2.39 ± 0.06^†	1.5 ± 0.3
Muscle	0.12 ± 0.05^*^†	0.24 ± 0.05	0.05 ± 0.02^†	0.13 ± 0.04
Bone	0.4 ± 0.1^*^†	0.9 ± 0.3	0.37 ± 0.08^†	0.7 ± 0.3
Brain	0.013 ± 0.004^*^†	0.020 ± 0.003^*	NM	0.010 ± 0.005^*
GI tract^‡	1.7 ± 0.3^*^†	3.5 ± 0.5^*	0.6 ± 0.1^*^†	1.4 ± 0.1^*
Carcass^‡	3.8 ± 0.4^*^†	9.0 ± 1.0	2.0 ± 0.3^*^†	5.8 ± 1.3^*

↵* Significant difference (P < 0.05, paired t test) between uptake after injection of 3 and 50 μg of tracer.
↵† Significant difference (P < 0.05, unpaired t test) between ¹¹¹In-Bz-DTPA-Z_EGFR:1907 and ¹¹¹In-Bz-DTPA-(Z_EGFR:1907)₂.
↵‡ Data for gastrointestinal (GI) tract and carcass are presented as %IA per sample.
NM = nonmeasurable.
Data are presented as average %IA/g and SD (n = 4).