Data Fixed or Weighted with Bayesian Parameters for Each Organ
| Site | Fi* (%) | Vi* (%) | λphy111In (1/min) |
|---|---|---|---|
| Liver† | 6.5 (arterial), 25.5 ± 2‡ (total) | 10 | |
| Spleen | 3 ± 2§ | 1.4 | |
| Red marrow | 3 ± 3§ | 4 | 1.72 × 104 |
| Lymph nodes | 1.7 | 0.2 | |
| Gastrointestinal tract | 16 | 7.6 | |
| Plasma‖ | — | 66.8 |
↵* Data are from Leggett et al. (30).
↵† Liver is supported by direct arterial flow (6.5% of total blood flow), plus portal flow from gastrointestinal tract (16%) plus flow from spleen (3%).
↵‡ SD ± 2 stems from Bayesian term of spleen.
↵‖ Plasma includes blood pools other than liver, spleen, red marrow, and lymph nodes. Exchange between veins, arteries, heart, and other blood pools is fast, and therefore blood pools of organs with no antigen site can be simplified to one.
↵§ Blood flows were determined using Bayesian term. For flow to lymph nodes, mean population value was used since no direct measurement of lymph node time–activity curve would otherwise yield high uncertainties for both its flow and number of antigens. Arterial flow to liver was fixed because starting value of 6.5% was also fitted value in all cases.